A pilot feasibility study of non-myeloablative allogeneic hematopoietic stem cell transplantation for refractory Crohn Disease

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    Burt RK, Craig RM, Milanetti F, et al. Autologous nonmyeloablative hematopoietic stem cell transplantation in patients with severe anti-TNF refractory crohn disease: long-term follow-up. Blood. 2010;116:6123–32.

    CAS  Article  Google Scholar 

  2. 2.

    Ruiz MA, Kaiser RL, Jr, de Quadros LG. et al. Low toxicity and favorable clinical and quality of life impact after non-myeloablative autologous hematopoietic stem cell transplant in crohn’s disease. BMC Res Notes. 2017;10:495-017-2824-1.

    Article  Google Scholar 

  3. 3.

    Lopez-Garcia A, Rovira M, Jauregui-Amezaga A, et al. Autologous haematopoietic stem cell transplantation for refractory crohn’s disease: efficacy in a single-centre cohort. J Crohns Colitis. 2017;11:1161–8.

    Article  Google Scholar 

  4. 4.

    Cassinotti A, Annaloro C, Ardizzone S, Onida F, Della Volpe A, Clerici M, et al. Autologous haematopoietic stem cell transplantation without CD34+ cell selection in refractory Crohn’s disease. Gut. 2008;57:211–7.

    CAS  Article  Google Scholar 

  5. 5.

    Hasselblatt P, Drognitz K, Potthoff K, et al. Remission of refractory crohn’s disease by high-dose cyclophosphamide and autologous peripheral blood stem cell transplantation. Aliment Pharmacol Ther. 2012;36:725–35.

    CAS  Article  Google Scholar 

  6. 6.

    Scimè R, Cavallaro AM, Tringali S, Santoro A, Rizzo A, Montalbano L, et al. Complete clinical remission after high-dose immune suppression and autologous hematopoietic stem cell transplantation in severe Crohn’s disease refractory to immunosuppressive and immunomodulator therapy. Inflamm Bowel Dis. 2004;10:892–4.

    Article  Google Scholar 

  7. 7.

    Hommes DW, Duijvestein M, Zelinkova Z, Stokkers PC, Ley MH, Stoker J, et al. Long-term follow-up of autologous hematopoietic stem cell transplantation for severe refractory Crohn’s disease. J Crohns Colitis. 2011;5:543–9.

    Article  Google Scholar 

  8. 8.

    Snowden JA, Panés J, Alexander T, Allez M, Ardizzone S, Dierickx D, et al. Autologous Haematopoietic Stem Cell Transplantation (AHSCT) in severe Crohn’s disease: a review on behalf of ECCO and EBMT. J Crohns Colitis. 2018;12:476–88.

  9. 9.

    Hawkey CJ, Allez M, Clark MM, et al. Autologous hematopoetic stem cell transplantation for refractory crohn disease: a randomized clinical trial. JAMA. 2015;314:2524–34.

    CAS  Article  Google Scholar 

  10. 10.

    Lindsay JO, Allez M, Clark M, Labopin M, Ricart E, Rogler G, et al. Autologous stem-cell transplantation in treatment-refractory Crohn’s disease: an analysis of pooled data from the ASTIC trial. ASTIC trial group; European Society for Blood and Marrow Transplantation Autoimmune Disease Working Party; European Crohn’s and Colitis Organisation. Lancet Gastroenterol Hepatol. 2017;2:399–406.

    Article  Google Scholar 

  11. 11.

    Slavin S, Nagler A, Varadi G, Or R. Graft vs autoimmunity following allogeneic non-myeloablative blood stem cell transplantation in a patient with chronic myelogenous leukemia and severe systemic psoriasis and psoriatic polyarthritis. Exp Hematol. 2000;28:853–7.

    CAS  Article  Google Scholar 

  12. 12.

    Zhang J, Lv S, Liu X, Song B, Shi L. Umbilical cord mesenchymal stem cell treatment for Crohn’s disease: a randomized controlled clinical trial. Gut liver. 2018;12:73–8.

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Richard K. Burt.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Burt, R.K., Craig, R., Yun, L. et al. A pilot feasibility study of non-myeloablative allogeneic hematopoietic stem cell transplantation for refractory Crohn Disease. Bone Marrow Transplant (2020). https://doi.org/10.1038/s41409-020-0953-y

Download citation