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Building a hematopoietic cell transplantation outcomes registry in Mexico

Bone Marrow Transplantation volume 55, pages 2279–2285 (2020)Cite this article

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Abstract

The aim of this study was to assess the feasibility of hematopoietic cell transplantation (HCT) data collection using an electronic platform at Mexican centers. Four public centers performing HCT in adults were included. A cloud-based electronic platform in Spanish was developed to allow real-time registration of demographic, clinical, and outcomes variables. Data were obtained from paper and electronic medical records and institutional databases. Data managers were hired to perform the collection. Data from January 2015 to December 2018 were retro and prospectively collected during a 10-month period. From 2015 to 2018, 473 HCT were performed. Most were autologous (55%). Patients undergoing autologous HCT had the highest median age (49 years) compared with patients undergoing allogeneic (34 years) or haploidentical HCT (29 years). The most common underlying disease for autologous HCT was multiple myeloma. Acute leukemias were the most common diagnoses among allogeneic and haploidentical HCT recipients. Two-year nonrelapse mortality was 2.5%, 18%, and 18% for autologous, allogeneic, and haploidentical HCT, respectively. We determined it was feasible to start a multicenter collaborative study in Mexico as it was very well received by the physicians and it can lead to the creation of a Mexican HCT Registry in the near future.

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Fig. 1: Algorithm of data collection.
Fig. 2: Number of HCT by type and year.
Fig. 3

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Acknowledgements

We would like to thank the data managers Edgar, Margarita, and Melissa who participated in this project.

Funding

This work was funded by a 2018 Conquer Cancer Foundation of ASCO Global Oncology Young Investigator Award (ID 12996). Any opinions, findings, and conclusions expressed in this material are those of the authors and do not necessarily reflect those of the American Society of Clinical Oncology® or the Conquer Cancer Foundation.

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Authors and Affiliations

  1. Hematopoietic Stem Cell Transplantation Program, Department of Hematology and Oncology, Instituto Nacional de Ciencias Medicas y Nutricion “Salvador Zubiran”, Mexico City, Mexico

    Monica M. Rivera-Franco & Eucario Leon-Rodriguez

  2. Hematology Service, Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, NL, Mexico

    David Gómez-Almaguer & Cesar H. Gutiérrez-Aguirre

  3. Hematopoietic Stem Cell Transplantation Program, Department of Hematology, Instituto Nacional de Cancerología, Mexico City, Mexico

    Luis M. Valero-Saldaña & Brenda L. Acosta-Maldonado

  4. Hematology Service, Unidad Médica de Alta Especialidad “Manuel Avila Camacho”, Instituto Mexicano del Seguro Social, Puebla, PL, Mexico

    Jose A. Limón-Flores & Uendy Pérez-Lozano

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  1. Monica M. Rivera-Franco
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  2. Eucario Leon-Rodriguez
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Correspondence to Eucario Leon-Rodriguez.

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Rivera-Franco, M.M., Leon-Rodriguez, E., Gómez-Almaguer, D. et al. Building a hematopoietic cell transplantation outcomes registry in Mexico. Bone Marrow Transplant 55, 2279–2285 (2020). https://doi.org/10.1038/s41409-020-0944-z

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