Regression of oral proliferative leukoplakia following initiation of ibrutinib therapy in two allogeneic hematopoietic stem cell transplant recipients

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References

  1. 1.

    Mays JW, Fassil H, Edwards DA, Pavletic SZ, Bassim CW. Oral chronic graft-versus-host disease: current pathogenesis, therapy, and research. Oral Dis. 2013;19:327–46. https://doi.org/10.1111/odi.12028

  2. 2.

    Mawardi H, Elad S, Correa ME, Stevenson K, Woo SB, Almazrooa S, et al. Oral epithelial dysplasia and squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation: clinical presentation and treatment outcomes. Bone Marrow Transplant. 2011;46:884–91. https://doi.org/10.1038/bmt.2011.77

  3. 3.

    Hanna GJ, Kofman ER, Shazib MA, Woo SB, Reardon B, Treister NS, et al. Integrated genomic characterization of oral carcinomas in post-hematopoietic stem cell transplantation survivors. Oral Oncol. 2018;81:1–9. https://doi.org/10.1016/j.oraloncology.2018.04.007

  4. 4.

    Mohty B, Mohty M. Long-term complications and side effects after allogeneic hematopoietic stem cell transplantation: an update. Blood Cancer J. 2011;1:e16–e16. https://doi.org/10.1038/bcj.2011.14

  5. 5.

    Villa A, Menon RS, Kerr AR, De Abreu Alves F, Guollo A, Ojeda D, et al. Proliferative leukoplakia: Proposed new clinical diagnostic criteria. Oral Dis. 2018;24:749–60. https://doi.org/10.1111/odi.12830

  6. 6.

    Borgna SC, Clarke PT, Schache AG, Lowe D, Ho MW, McCarthy CE, et al. Management of proliferative verrucous leukoplakia: justification for a conservative approach. Head Neck. 2017;39:1997–2003. https://doi.org/10.1002/hed.24845

  7. 7.

    Miklos D, Cutler CS, Arora M, Waller E, Jagasia M, Pusic I, et al. Ibrutinib for chronic graft-versus-host disease after failure of prior therapy. Blood. 2017;130:2243–50. https://doi.org/10.1182/blood-2017-07-793786

  8. 8.

    Torres-Pereira C, Funke V, Giovanini AF, Lemos CA Jr, Amenabar JM, Piazzetta CM. Oral proliferative verrucous leukoplakia (PVL) in a post-bone marrow transplant patient. Biol Blood Marrow Transplant. 2008;14:1197–9. https://doi.org/10.1016/j.bbmt.2008.07.012

  9. 9.

    Leite Carvalhaes CL, Nunes Vilela MC, Fernandes KSÁ, Lascane NA, Da Silva Santos PS, Mantesso A, et al. Leukoplakia lesion in a patient with history of graft-versus-host disease. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117:e126. https://doi.org/10.1016/j.oooo.2013.10.049

  10. 10.

    Hansen LS, Olson JA, Silverman S Jr. Proliferative verrucous leukoplakia. A long-term study of thirty patients. Oral Surg Oral Med Oral Pathol. 1985;60:285–98. https://doi.org/10.1016/0030-4220(85)90313-5

  11. 11.

    Yagyuu T, Hatakeyama K, Imada M, Kurihara M, Matsusue Y, Yamamoto K, et al. Programmed death ligand 1 (PD-L1) expression and tumor microenvironment: Implications for patients with oral precancerous lesions. Oral Oncol. 2017;68:36–43. https://doi.org/10.1016/j.oraloncology.2017.03.006

  12. 12.

    Sloand EM, Pfannes L, Ling C, Feng X, Jasek M, Calado R, et al. Graft-versus-host disease: role of inflammation in the development of chromosomal abnormalities of keratinocytes. Biol Blood Marrow Transplant. 2010;16:1665–73. https://doi.org/10.1016/j.bbmt.2010.07.014

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Correspondence to Paolo J. Fantozzi.

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Fantozzi, P.J., Villa, A., Antin, J.H. et al. Regression of oral proliferative leukoplakia following initiation of ibrutinib therapy in two allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplant (2020). https://doi.org/10.1038/s41409-020-0889-2

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