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CD8+CD161hi T cells are associated with acute graft-versus-host disease after haploidentical hematopoietic stem cell transplantation

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Fig. 1: Effect of CD8+CD161hi T cells in G-CSF primed peripheral blood allografts on gut aGVHD, NRM, OS, and relapse.

References

  1. Fergusson JR, Smith KE, Fleming VM, Rajoriya N, Newell EW, Simmons R, et al. CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages. Cell Rep. 2014;9:1075–88.

    Article  CAS  Google Scholar 

  2. Ussher JE, Bilton M, Attwod E, Shadwell J, Richardson R, de Lara C, et al. CD161++CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner. Eur J Immunol. 2014;44:195–203.

    Article  CAS  Google Scholar 

  3. Lee SE, Lim JY, Yoon JH, Shin SH, Cho BS, Eom KS, et al. CD161(+) T cells as predictive markers for acute graft-versus-host disease. Biol Blood Marrow Transplant. 2015;21:421–8.

    Article  CAS  Google Scholar 

  4. Bhattacharyya A, Hanafi LA, Sheih A, Golob JL, Srinivasan S, Boeckh MJ, et al. Graft-derived reconstitution of mucosal-associated invariant T cells after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2018;24:242–51.

    Article  CAS  Google Scholar 

  5. Wang Y, Wang HX, Lai YR, Sun ZM, Wu DP, Jiang M, et al. Haploidentical transplant for myelodysplastic syndrome: registry-based comparison with identical sibling transplant. Leukemia. 2016;30:2055–63.

    Article  CAS  Google Scholar 

  6. Walker LJ, Kang Y-H, Smith MO, Tharmalingham H, Ramamurthy N, Fleming VM, et al. Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells. Blood. 2012;119:422–33.

    Article  CAS  Google Scholar 

  7. Shono Y, Docampo MD, Peled JU, Perobelli SM, Velardi E, Tsai JJ, et al. Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice. Sci Transl Med. 2016;8:339ra371.

    Article  Google Scholar 

  8. Jenq RR, Ubeda C, Taur Y, Menezes CC, Khanin R, Dudakov JA, et al. Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. J Exp Med. 2012;209:903–11.

    Article  CAS  Google Scholar 

  9. Robertson Parkman KIW. Immunological reconstitution following bone marrow transplantation. Immunol Rew. 1997;157:73–78.

    Article  Google Scholar 

  10. van der Waart AB, van der Velden WJ, van Halteren AG, Leenders MJ, Feuth T, Blijlevens NM, et al. Decreased levels of circulating IL17-producing CD161+CCR6+ T cells are associated with graft-versus-host disease after allogeneic stem cell transplantation. PLoS ONE. 2012;7:e50896.

    Article  Google Scholar 

  11. Gherardin NA, Souter MNT, Koay H-F, Mangas KM, Seemann T, Stinear TP, et al. Human blood MAIT cell subsets defined using MR1 tetramers. Immunol Cell Biol. 2018;96:507–25.

    Article  CAS  Google Scholar 

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Correspondence to Xiaosu Zhao.

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Hong, Y., Liu, L., Chang, Y. et al. CD8+CD161hi T cells are associated with acute graft-versus-host disease after haploidentical hematopoietic stem cell transplantation. Bone Marrow Transplant 55, 1652–1654 (2020). https://doi.org/10.1038/s41409-020-0842-4

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