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Improved outcomes of allogeneic hematopoietic stem cell transplantation including haploidentical transplantation for childhood myelodysplastic syndrome

Bone Marrow Transplantation volume 55, pages 1595–1603 (2020)Cite this article

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Abstract

This retrospective study aimed to investigate the outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) for childhood myelodysplastic syndrome (MDS). Thirty-six patients (low-grade MDS, 24; advanced MDS, 12) received HSCT at the Asan Medical Center over two decades (early period, 1997–2007; recent period, 2008–2017). The transplantation outcomes were analyzed according to disease status, conditioning regimen, various donor types, and period of HSCT. During a median follow-up of 5.6 (range, 1.4–21.1) years, the probability of overall survival (OS) and failure-free survival was 77% and 69%, respectively. The cumulative incidence of transplantation-related mortality (TRM) was 12%. Significantly reduced TRM and improved OS were observed in patients who received HSCT during the recent period vs. the early period (TRM, 4% vs. 30%, P = 0.021; OS, 87% vs. 50%, P = 0.006). Comparable outcomes were observed for HSCT from haploidentical family donors vs. HLA-identical donors (TRM, 10% vs. 14%, P = 0.837; OS, 86% vs. 79%, P = 0.625). This study identified the improved outcomes of allogeneic HSCT for childhood MDS over time, in addition, the feasible outcomes of haploidentical HSCT suggested its use as an attractive alternative in the future procedures.

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Acknowledgements

This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI10C2020).

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Authors and Affiliations

  1. Department of Pediatrics, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon, Korea

    Jae Won Yoo

  2. Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center Children’s Hospital, Seoul, Korea

    Jae Won Yoo, Ho Joon Im, Hyery Kim, Kyung-Nam Koh, Sung Han Kang, So Yoon Min, Eun Seok Choi & Jong Jin Seo

  3. Department of Laboratory medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

    Seongsoo Jang & Chan-Jeoung Park

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  1. Jae Won Yoo
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Yoo, J.W., Im, H.J., Kim, H. et al. Improved outcomes of allogeneic hematopoietic stem cell transplantation including haploidentical transplantation for childhood myelodysplastic syndrome. Bone Marrow Transplant 55, 1595–1603 (2020). https://doi.org/10.1038/s41409-020-0814-8

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