Excellent outcomes of allogeneic transplantation from peripheral blood of HLA-matched related donors for adult sickle cell disease with ATLG and posttransplant cyclophosphamide-containing regimen: an update work

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Fig. 1: Overall survival and disease-free survival curves.

References

  1. 1.

    Walters MC, De Castro LM, Sullivan KM, Krishnamurti L, Kamani N, Bredeson C, et al. Indications and results of HLA-identical sibling hematopoietic cell transplantation for sickle cell disease. Biol Blood Marrow Transplant. 2016;22:207–11.

    Article  Google Scholar 

  2. 2.

    Elmariah H, Garrett ME, De Castro LM, Jonassaint JC, Ataga KI, Echman JE, et al. Factors associated with survival in a contemporary adult sickle cell disease cohort. Am J Hematol. 2014;89:530–35.

    CAS  Article  Google Scholar 

  3. 3.

    Fitzhugh CD, Abraham AA, Tisdale J. Hematopoietic stem cell transplantation for patients with sickle cell disease: progress and future directions. Hematol Oncol Clin North Am. 2014;28:1171–85.

    Article  Google Scholar 

  4. 4.

    Ozdoğu H, Boga C. Hematopoietic stem cell transplantation in adult sickle cell disease: problems and solutions. Turk J Haematol. 2015;32:195–205.

    Article  Google Scholar 

  5. 5.

    Hsieh MM, Fitzhugh CD, Weitzel RP, Link ME, Coles WA, Zhao X, et al. Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype. J Am Med Assoc. 2014;312:48–56.

    Article  Google Scholar 

  6. 6.

    Hsieh MM. A standard nonmyeloablative transplantation regimen for adults with sickle cell disease: are we there yet? Biol Blood Marrow Transplant. 2016;22:397–8.

    Article  Google Scholar 

  7. 7.

    Ozdogu H, Boga C, Yeral M, Kozanoglu I, Gereklioglu C, Aytan P, et al. Allogeneic peripheral stem cell transplantation from HLA-matched related donors for adult sickle cell disease: remarkable outcomes from a single-center trial. Bone Marrow Transplant. 2018;53:880–90.

    CAS  Article  Google Scholar 

  8. 8.

    Gluckman E, Cappelli B, Bernaudin F, Labopin M, Volt F, Carreras J, et al. Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation. Blood. 2017;129:1548–56.

    CAS  Article  Google Scholar 

  9. 9.

    Bolaños-Meade J, Fuchs EJ, Luznik L, Lanzkron SM, Gamper CJ, Jones RJ, et al. HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease. Blood. 2012;120:4285–91.

    Article  Google Scholar 

  10. 10.

    Saraf SL, Oh AL, Patel PR, Jalundhwala Y, Sweiss K, Koshy M, et al. Nonmyeloablative stem cell transplantation with alemtuzumab/low-dose irradiation to cure and improve the quality of life of adults with sickle cell disease. Biol Blood Marrow Transplant. 2016;22:441–8.

    CAS  Article  Google Scholar 

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Acknowledgements

We acknowledge Serdar Esen and Canan Cansun for their technical help.

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Correspondence to Hakan Ozdogu.

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Ozdogu, H., Boga, C., Yeral, M. et al. Excellent outcomes of allogeneic transplantation from peripheral blood of HLA-matched related donors for adult sickle cell disease with ATLG and posttransplant cyclophosphamide-containing regimen: an update work. Bone Marrow Transplant 55, 1647–1651 (2020). https://doi.org/10.1038/s41409-020-0805-9

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