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Excellent outcomes of allogeneic transplantation from peripheral blood of HLA-matched related donors for adult sickle cell disease with ATLG and posttransplant cyclophosphamide-containing regimen: an update work

Bone Marrow Transplantation volume 55, pages 1647–1651 (2020)Cite this article

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Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) for sickle cell disease (SCD) is considerably more difficult in adults than children, due to a greater risk of organ damage and other complications [1,2,3]. Perennial transplant-related problems include graft vs. host disease (GVHD), graft loss, infections, endothelial activation, and inflammation [1,2,3,4]. Successful outcomes in adults have recently been reported using chemotherapy or alemtuzumab-based non-myeloablative conditioning [5, 6]. Until recently, around 300 adults are listed in the international registries.

We previously reported the improved outcomes in adult SCD patients who underwent allo-HSCT from peripheral blood [7]. Given the limited number of SCD adults receiving transplants from peripheral blood worldwide, we considered to share the updated outcomes of a reasonably large number of cases. Data were validated by an independent data audit team from an affiliated JACIE-accredited center. Local ethics committee approval was obtained prior to the study (KA18/143).

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Fig. 1: Overall survival and disease-free survival curves.

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Acknowledgements

We acknowledge Serdar Esen and Canan Cansun for their technical help.

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Authors and Affiliations

  1. Department of Hematology and Adana Adult Bone Marrow Transplantation Centre, University of Baskent, Ankara, Turkey

    Hakan Ozdogu, Can Boga, Mahmut Yeral, Pelin Aytan, Mutlu Kasar & Nurhilal Buyukkurt

  2. Department of Physiology and Adana Adult Bone Marrow Transplantation Centre, University of Baskent, Ankara, Turkey

    Ilknur Kozanoglu

  3. Department of Family Medicine, University of Baskent, Ankara, Turkey

    Cigdem Gereklioglu, Suheyl Asma & Aslı Korur

  4. Medical Statistics, Adana Hospital, University of Baskent, Ankara, Turkey

    Cagla Sariturk

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  1. Hakan Ozdogu
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Correspondence to Hakan Ozdogu.

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Ozdogu, H., Boga, C., Yeral, M. et al. Excellent outcomes of allogeneic transplantation from peripheral blood of HLA-matched related donors for adult sickle cell disease with ATLG and posttransplant cyclophosphamide-containing regimen: an update work. Bone Marrow Transplant 55, 1647–1651 (2020). https://doi.org/10.1038/s41409-020-0805-9

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