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Longitudinal tracking of skin dynamic stiffness to quantify evolution of sclerosis in chronic graft-versus-host disease

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Fig. 1: Average dynamic stiffness measurements and linear regression slopes.

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Acknowledgements

This work was supported by Career Development Award Number IK2 CX001785 from the United States Department of Veterans Affairs Clinical Science R&D Service and NIH K12 CA090625. The authors are grateful for the patients and volunteers who participated in this study.

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E.T., M.J., and F.C. designed the study. IRB for the study was written by E.T. Chart review was completed by L.B. and confirmed with M.B. and T.K.; A.V. and E.T. developed the Myoton measurement protocol and trained L.B., F.C., and Y.S. to perform Myoton measurements. Subject measurements were performed by L.B. (35 measurement sessions), F.C. (24 sessions), and Y.S. (11 sessions). Analysis including linear regression was conceived by L.B.; L.B. performed the analysis, and Y.S. independently checked the analysis, beginning with raw data from Myoton device. L.B. created all figures and wrote the manuscript drafts, and all co-authors participated in revisions. E.T. was responsible for all aspects of the study.

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Correspondence to Eric R. Tkaczyk.

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The authors declare that they have no conflict of interest. A.V. is the inventor of the Myoton but has no financial interest in the device.

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Baker, L.X., Chen, F., Ssempijja, Y. et al. Longitudinal tracking of skin dynamic stiffness to quantify evolution of sclerosis in chronic graft-versus-host disease. Bone Marrow Transplant 56, 989–991 (2021). https://doi.org/10.1038/s41409-020-01158-w

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