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Longitudinal tracking of skin dynamic stiffness to quantify evolution of sclerosis in chronic graft-versus-host disease

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Fig. 1: Average dynamic stiffness measurements and linear regression slopes.


  1. 1.

    Inamoto Y, Storer BE, Petersdorf EW, Nelson JL, Lee SJ, Carpenter PA, et al. Incidence risk factors, and outcomes of sclerosis in patients with chronic graft-versus-host disease. Blood 2013;121:5098–103.

    CAS  Article  Google Scholar 

  2. 2.

    Lee SJ, Wolff D, Kitko C, Koreth J, Inamoto Y, Jagasia M, et al. Measuring therapeutic response in chronic graft-versus-host disease. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: IV. The 2014 Response Criteria Working Group report. Biol Blood Marrow Transpl. 2015;21:984–99.

    Article  Google Scholar 

  3. 3.

    Cowen EW. Decoding skin involvement in chronic graft-vs-host disease. JAMA Dermatol. 2019;155:777–8.

    Article  Google Scholar 

  4. 4.

    Vain A. inventor; Myoton AS, assignee. Device and method for real-time measurement of parameters of mechanical stress state and biomechanical properties of soft biological tissue. 2011. US 20130289365 A1.

  5. 5.

    Chen F, Dellalana LE, Gandelman JS, Vain A, Jagasia MH, Tkaczyk ER. Non-invasive measurement of sclerosis in cutaneous cGVHD patients with the handheld device Myoton: a cross-sectional study. Bone Marrow Transpl. 2019;54:616–9.

    Article  Google Scholar 

  6. 6.

    Mridha M, Odman S. Characterization of subcutaneous edema by mechanical impedance measurements. J Invest Dermatol. 1985;85:575–8.

    CAS  Article  Google Scholar 

  7. 7.

    Mitchell SA, Jacobsohn D, Thormann Powers KE, Carpenter PA, Flowers ME, Cowen EW, et al. A multicenter pilot evaluation of the National Institutes of Health chronic graft-versus-host disease (cGVHD) therapeutic response measures: feasibility, interrater reliability, and minimum detectable change. Biol Blood Marrow Transpl. 2011;17:1619–29.

    Article  Google Scholar 

  8. 8.

    Dellalana LE, Chen F, Vain A, Gandelman JS, Põldemaa M, Chen H, et al. Reproducibility of the durometer and myoton devices for skin stiffness measurement in healthy subjects. Skin Res Technol. 2019;25:289–93.

    Article  Google Scholar 

  9. 9.

    Chen F, Wang L, Vain A, Ssempijja Y, Dellalana L, Zhang K, et al. Interobserver reproducibility of the Myoton and Durometer devices to measure skin stiffness and hardness in chronic cutaneous graft-versus-host disease patients. Blood. 2019;134:4515.

    Article  Google Scholar 

  10. 10.

    Palma L, Marques LT, Bujan J, Rodrigues LM. Dietary water affects human skin hydration and biomechanics. Clin Cosmet Investig Dermatol. 2015;8:413–21.

    CAS  PubMed  PubMed Central  Google Scholar 

  11. 11.

    Tsukahara K, Takema Y, Moriwaki S, Fujimura T, Imokawa G. Dermal fluid translocation is an important determinant of the diurnal variation in human skin thickness. Br J Dermatol. 2001;145:590–96.

    CAS  Article  Google Scholar 

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This work was supported by Career Development Award Number IK2 CX001785 from the United States Department of Veterans Affairs Clinical Science R&D Service and NIH K12 CA090625. The authors are grateful for the patients and volunteers who participated in this study.

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E.T., M.J., and F.C. designed the study. IRB for the study was written by E.T. Chart review was completed by L.B. and confirmed with M.B. and T.K.; A.V. and E.T. developed the Myoton measurement protocol and trained L.B., F.C., and Y.S. to perform Myoton measurements. Subject measurements were performed by L.B. (35 measurement sessions), F.C. (24 sessions), and Y.S. (11 sessions). Analysis including linear regression was conceived by L.B.; L.B. performed the analysis, and Y.S. independently checked the analysis, beginning with raw data from Myoton device. L.B. created all figures and wrote the manuscript drafts, and all co-authors participated in revisions. E.T. was responsible for all aspects of the study.

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Correspondence to Eric R. Tkaczyk.

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The authors declare that they have no conflict of interest. A.V. is the inventor of the Myoton but has no financial interest in the device.

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Baker, L.X., Chen, F., Ssempijja, Y. et al. Longitudinal tracking of skin dynamic stiffness to quantify evolution of sclerosis in chronic graft-versus-host disease. Bone Marrow Transplant 56, 989–991 (2021).

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