Subscribe to Journal
Get full journal access for 1 year
only $33.25 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Inamoto Y, Storer BE, Petersdorf EW, Nelson JL, Lee SJ, Carpenter PA, et al. Incidence risk factors, and outcomes of sclerosis in patients with chronic graft-versus-host disease. Blood 2013;121:5098–103.
Lee SJ, Wolff D, Kitko C, Koreth J, Inamoto Y, Jagasia M, et al. Measuring therapeutic response in chronic graft-versus-host disease. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: IV. The 2014 Response Criteria Working Group report. Biol Blood Marrow Transpl. 2015;21:984–99.
Cowen EW. Decoding skin involvement in chronic graft-vs-host disease. JAMA Dermatol. 2019;155:777–8.
Vain A. inventor; Myoton AS, assignee. Device and method for real-time measurement of parameters of mechanical stress state and biomechanical properties of soft biological tissue. 2011. US 20130289365 A1.
Chen F, Dellalana LE, Gandelman JS, Vain A, Jagasia MH, Tkaczyk ER. Non-invasive measurement of sclerosis in cutaneous cGVHD patients with the handheld device Myoton: a cross-sectional study. Bone Marrow Transpl. 2019;54:616–9.
Mridha M, Odman S. Characterization of subcutaneous edema by mechanical impedance measurements. J Invest Dermatol. 1985;85:575–8.
Mitchell SA, Jacobsohn D, Thormann Powers KE, Carpenter PA, Flowers ME, Cowen EW, et al. A multicenter pilot evaluation of the National Institutes of Health chronic graft-versus-host disease (cGVHD) therapeutic response measures: feasibility, interrater reliability, and minimum detectable change. Biol Blood Marrow Transpl. 2011;17:1619–29.
Dellalana LE, Chen F, Vain A, Gandelman JS, Põldemaa M, Chen H, et al. Reproducibility of the durometer and myoton devices for skin stiffness measurement in healthy subjects. Skin Res Technol. 2019;25:289–93.
Chen F, Wang L, Vain A, Ssempijja Y, Dellalana L, Zhang K, et al. Interobserver reproducibility of the Myoton and Durometer devices to measure skin stiffness and hardness in chronic cutaneous graft-versus-host disease patients. Blood. 2019;134:4515.
Palma L, Marques LT, Bujan J, Rodrigues LM. Dietary water affects human skin hydration and biomechanics. Clin Cosmet Investig Dermatol. 2015;8:413–21.
Tsukahara K, Takema Y, Moriwaki S, Fujimura T, Imokawa G. Dermal fluid translocation is an important determinant of the diurnal variation in human skin thickness. Br J Dermatol. 2001;145:590–96.
This work was supported by Career Development Award Number IK2 CX001785 from the United States Department of Veterans Affairs Clinical Science R&D Service and NIH K12 CA090625. The authors are grateful for the patients and volunteers who participated in this study.
Conflict of interest
The authors declare that they have no conflict of interest. A.V. is the inventor of the Myoton but has no financial interest in the device.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Baker, L.X., Chen, F., Ssempijja, Y. et al. Longitudinal tracking of skin dynamic stiffness to quantify evolution of sclerosis in chronic graft-versus-host disease. Bone Marrow Transplant 56, 989–991 (2021). https://doi.org/10.1038/s41409-020-01158-w