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MicroRNAs in graft-versus-host disease: a review of the latest data

Bone Marrow Transplantation volume 55, pages 1014–1020 (2020)Cite this article

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Abstract

Detectable in biopsies and body fluids, the measurement of a single or panels of microRNAs have been reported to be quite sensitive and specific for the prediction, diagnosis, and prognosis of many diseases. Interest in the use of microRNAs as biomarkers and eventual therapeutic targets has increased exponentially in the last decade. However, in the field of graft-versus-host disease (GVHD), the discovery of their involvement in biological processes and their predictive value is only emerging. With 30–75% of patients developing GVHD following allogeneic hematopoietic cell transplant and the absence of routinely used predictive biomarkers, microRNAs are promising for early detection and follow-up of this condition. We aim to summarize the current knowledge on the involvement of these small RNAs in the pathophysiology of this disease. We also review studies investigating the potential of miRNAs as biomarkers for early detection, follow-up, and prognosis of GVHD.

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Funding

This work was supported in part by grants from the Cancer Research Society of Canada (grants no. 22669 to MG), and the Fonds de recherche du Québec-Santé (FRQS).

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  1. These authors contributed equally: V. De Guire, I. Ahmad

Authors and Affiliations

  1. Haematology and Medical Oncology, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montreal, QC, Canada

    M. Newmarch, J. Roy & I. Ahmad

  2. Biochemistry, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montreal, QC, Canada

    E. Kostantin & V. De Guire

  3. Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center and The Audrey and Theodor Geisel School of Medicine at Dartmouth, Lebanon, NH, USA

    G. J. Tsongalis

  4. Department of Microbiology, Infectious Diseases & Immunology, Université de Montréal, Montreal, QC, Canada

    M. Guimond

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Newmarch, M., Kostantin, E., Tsongalis, G.J. et al. MicroRNAs in graft-versus-host disease: a review of the latest data. Bone Marrow Transplant 55, 1014–1020 (2020). https://doi.org/10.1038/s41409-019-0764-1

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