Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Unrelated cord blood transplantation for severe aplastic anemia using intensified immunoablative conditioning regimen leading to high engraftment and survival

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1

References

  1. Niederwieser D, Baldomero H, Szer J, Gratwohl M, Aljurf M, Atsuta Y, et al. Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for blood and marrow transplantation group including the global survey. Bone Marrow Transpl. 2016;51:778–85.

    Article  CAS  Google Scholar 

  2. Yoshimi A, Kojima S, Taniguchi S, Hara J, Matsui T, Takahashi Y, et al. Unrelated cord blood transplantation for severe aplastic anemia. Biol Blood Marrow Transplant. 2008;14:1057–63.

    Article  CAS  Google Scholar 

  3. Peffault de Latour R, Purtill D, Ruggeri A, Sanz G, Michel G, Gandemer V, et al. Influence of nucleated cell dose on overall survival of unrelated cord blood transplantation for patients with severe acquired aplastic anemia: a study by eurocord and the aplastic anemia working party of the European group for blood and marrow transplantation. Biol Blood Marrow Transplant. 2011;17:78–85.

    Article  Google Scholar 

  4. Yamamoto H, Kato D, Uchida N, Ishiwata K, Araoka H, Takagi S, et al. Successful sustained engraftment after reduced-intensity umbilical cord blood transplantation for adult patients with severe aplastic anemia. Blood 2011;117:3240–2.

    Article  CAS  Google Scholar 

  5. Peffault de Latour R, Chevret S, Jubert C, Sirvent A, Galambrun C, Ruggeri A, et al. Unrelated cord blood transplantation in patients with acquired refractory aplastic anemia: a nationwide phase II study. Blood 2018;132:750–4.

    Article  CAS  Google Scholar 

  6. Ochi T, Onishi Y, Nasu K, Onodera K, Kobayashi M, Ichikawa S, et al. Umbilical cord blood transplantation using reduced-intensity conditioning without antithymocyte globulin in adult patients with severe aplastic anemia. Biol Blood Marrow Transplant. 2019;25:e55–e59.

    PubMed  Google Scholar 

  7. Kuwatsuka Y, Kanda J, Yamazaki H, Mori T, Miyamura K, Kako S, et al. A comparison of outcomes for cord blood transplantation and unrelated bone marrow transplantation in adult aplastic anemia. Biol Blood Marrow Transplant. 2016;22:1836–43.

    PubMed  Google Scholar 

  8. Kudo K, Muramatsu H, Narita A, Yoshida N, Kobayashi R, Yabe H, et al. Unrelated cord blood transplantation in aplastic anemia:is anti-thymocyte globulin indispensable for conditioning? Bone Marrow Transpl. 2017;52:1659–61.

    Article  CAS  Google Scholar 

  9. Storb R, Leisenring W, Anasetti C, Appelbaum FR, Buckner CD, Bensinger WI, et al. Long-term follow-up of allogeneic marrow transplants in patients with aplastic anemia conditioned by cyclophosphamide combined with antithymocyte globulin. Blood. 1997;89:3890–1.

    Article  CAS  Google Scholar 

  10. Chan KW, McDonald L, Lim D, Grimley MS, Grayson G, Wall DA. Unrelated cord blood transplantation in children with idiopathic severe aplastic anemia. Bone Marrow Transpl. 2008;42:589–95.

    Article  CAS  Google Scholar 

  11. Tolar J, Deeg HJ, Arai S, Horwitz M, Antin JH, McCarty JM, et al. Fludarabine-based conditioning for marrow transplantation from unrelated donors in severe aplastic anemia: early results of a cyclophosphamide dose deescalation study show life-threatening adverse events at predefined cyclophosphamide dose levels. Biol Blood Marrow Transplant. 2012;18:1007–11.

    Article  CAS  Google Scholar 

  12. Xu LP, Wang SQ, Wu DP, Wang JM, Gao SJ, Jiang M, et al. Haplo-identical transplantation for acquired severe aplastic anaemia in a multicentre prospective study. Br J Haematol. 2016;175:265–74.

    Article  Google Scholar 

  13. Bacigalupo A, Socie’ G, Lanino E, Prete A, Locatelli F, Locasciulli A, et al. Fludarabine, cyclophosphamide, antithymocyte globulin, with or without low dose total body irradiation, for alternative donor transplants, in acquired severe aplastic anemia: a retrospective study from the EBMT-SAA Working Party. Haematologica. 2010;95(Jun):976–82.

    Article  CAS  Google Scholar 

  14. Pascal L, Mohty M, Ruggeri A, Tucunduva L, Milpied N, Chevallier P, et al. Impact of rabbit ATG-containing myeloablative conditioning regimens on the outcome of patients undergoing unrelated single-unit cord blood transplantation for hematological malignancies. Bone Marrow Transpl. 2015;50:45–50.

    Article  CAS  Google Scholar 

  15. Admiraal R, van Kesteren C, Jol-van der Zijde CM, Lankester AC, Bierings MB, Egberts TC, et al. Association between anti-thymocyte globulin exposure and CD4+ immune reconstitution in paediatric haemopoietic cell transplantation: a multicentre, retrospective pharmacodynamic cohort analysis. Lancet Haematol. 2015;2:e194–203.

    Article  Google Scholar 

Download references

Acknowledgements

The authors would like to thank all the patients and their families for participating in this study. The authors would like to thank the physicians, nurses, and support personnel for their care of patients in this study.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jiahua Ding.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Du, S., He, W., Yang, Y. et al. Unrelated cord blood transplantation for severe aplastic anemia using intensified immunoablative conditioning regimen leading to high engraftment and survival. Bone Marrow Transplant 55, 1677–1680 (2020). https://doi.org/10.1038/s41409-019-0736-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41409-019-0736-5

Search

Quick links