Table 1 Patient-, transplant-related characteristics and outcomes of the patients

From: Unrelated cord blood transplantation for severe aplastic anemia using intensified immunoablative conditioning regimen leading to high engraftment and survival

Case no. Age (year) Gender (D/R) Previous Treatment Weight /kg Time from diagnosis to UCBT, mo Condition regimen HLAc match TNC × 107/ kg CD34+ × 105/kg Days to ANC > 0.5 × 109/L Days to PC > 20 × 109/L Chimerism aGVHD cGVHD Complication Survival (mo)
1 14 F/F ISTb 48 48 FC 6/6 1.00 None 45 50 99% (30, PCR-STR) No No CMV 64.5+
2 20 M/F IST 55 18 FC 5/6 3.30 1.64 54 60 99.2% (21, FISH) No No CMV 55.7+
3 7 M/M IST 25 26 FC 6/6 5.60 3.40 17 23 97.2% (16, PCR-STR) II Limited No 50.3+
4 5 F/F IST 24 15 FC 6/6 6.30 1.88 12 18 98.4% (77, PCR-STR) II Limited CMV 46.9+
5 3 M/M IST 16 9 FC 4/6 12.00 5.00 15 30 98% (30, PCR-STR) II No CMV,
Epilepsy,
CNS infection
1.5d
6 15 M/F IST 50 38 FC 5/6 4.60 1.20 11 20 100% (12, FISH) III No CMV 38.2+
7 3 M/M IST 19 9 FBC 6/6 4.70 2.20 17 23 99.5% (38, PCR-STR) No No CMV 34.7+
8 4 M/M IST 18 14 FC 6/6 6.90 1.70 18 35 99.8% (27, PCR-STR) II Limited CMV 32.9+
9 3 M/F IST 15 10 FC 5/6 13.30 8.00 8 10 100% (21, FISH) No No CMV 28.2+
10 6 M/M CsA 25 15 FC 6/6 6.10 3.45 No No 1.1% (27, PCR-STR) No No No 2d
11 3 M/F CsA 14 13 FC 6/6 3.90 1.58 No No 8.7% (21, PCR-STR) No No No 2d
12 12 F/F CsA 40 3 FBC 5/6 5.40 2.08 17 21 99.9% (21, PCR-STR) No No CMV 14.3+
13 9 F/M CsA 35 50 FBC 4/6 7.32 1.97 18 42 100% (12, FISH) No No CMV 10.6+
14 11 M/F CsA 25 2 FBC 5/6 5.65 2.66 16 19 98.9% (9, IDP-qPCR) No No CMV 5.0+
15a 16 F/M
F/M
CsA 56 31 FBC 6/6
5/6
2.70
3.26
0.89
1.89
13 80 97.2% (9, IDP-qPCR) No CMV 3.0+
  1. IST Immunosuppressive therapy, TNC total nucleated cells, ANC absolute neutrophil count, PC platelet count, PCR-STR PCR of short tandem repeat, FISH fluorescence in situ hybridization, IDP-qPCR insertion or deletion polymorphisms of qPCR, aGVHD acute graft-versus-host disease, cGVHD chronic graft-versus-host disease, CMV cytomegalovirus, FC fludarabine + cyclophosphamide, FBC FC + busulfan, D/R donor/recipient, M man, F female, CsA cyclosporin A
  2. aReceived double units cord blood
  3. bIST = CsA + ATG
  4. cHLA match: A, B, DRB1
  5. dThe patient died