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Effect of low platelet HLA-C expression on donor-specific antibody depletion following platelet transfusion from a corresponding HLA donor

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  1. Takanashi M, Atsuta Y, Fujiwara K, Kodo H, Kai S, Sato H, et al. The impact of anti-HLA antibodies on unrelated cord blood transplantations. Blood. 2010;116:2839–46.

    Article  CAS  Google Scholar 

  2. Yoshihara S, Maruya E, Taniguchi K, Kaida K, Kato R, Inoue T, et al. Risk and prevention of graft failure in patients with preexisting donor-specific HLA antibodies undergoing unmanipulated 1 haploidentical SCT. Bone Marrow Transplant. 2012;47:508–15.

    Article  CAS  Google Scholar 

  3. Ciurea SO, Thall PF, Milton DR, Barnes TH, Kongtim P, Carmazzi Y, et al. Complement-binding donor-specific anti-HLA antibodies and risk of primary graft failure in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2015;21:1392–8.

    Article  CAS  Google Scholar 

  4. Yamashita T, Ikegame K, Kojima H, Tanaka H, Kaida K, Inoue T, et al. Effective desensitization of donor-specific HLA antibodies using platelet transfusion bearing targeted HLA in a case of HLA-mismatched allogeneic stem cell transplantation. Bone Marrow Transplant. 2017;52:794–6.

    Article  CAS  Google Scholar 

  5. Ciurea SO, Cao K, Fernandez-Vina M, Kongtim P, Malki MA, Fuchs E, et al. The European Society for Blood and Marrow Transplantation (EBMT) consensus guidelines for the detection and treatment of donor-specific anti-HLA antibodies (DSA) in haploidentical hematopoietic cell transplantation. Bone Marrow Transplant. 2018;53:521–34.

    Article  CAS  Google Scholar 

  6. Yoshihara S, Taniguchi K, Ogawa H, Saji H. The role of HLA antibodies in allogeneic SCT: is the ‘type-and-screen’ strategy necessary not only for blood type but also for HLA? Bone Marrow Transplant. 2012;47:1499–506.

    Article  CAS  Google Scholar 

  7. Datema G, Stein S, Eijsink C, Mulder A, Claas F, Doxiadis I. HLA-C expression on platelets: studies with an HLA-C1-specific human monoclonal antibody. Vox Sang. 2000;79:108–11.

    Article  CAS  Google Scholar 

  8. Spriewald BM, Bach C, Zingsem J, Strobel J, Winkler J, Mackensen A, et al. Depletion of donor-specific anti-HLA A2 alloantibodies in a hematopoietic cell transplant recipient using directed mismatched platelet transfusions. Bone Marrow Transplant. 2018;53:791–4.

    Article  Google Scholar 

  9. Narimatsu H, Wake A, Miura Y, Tanaka H, Matsumura T, Takagi S, et al. Successful engraftment in crossmatch-positive HLA-mismatched peripheral blood stem cell transplantation after depletion of antidonor cytotoxic HLA antibodies with rituximab and donor platelet infusion. Bone Marrow Transplant. 2005;36:555–6.

    Article  CAS  Google Scholar 

  10. Duquesnoy RJ, Filip DJ, Tomasulo PA, Aster RH. Role of HLA-C matching histocompatible platelet transfusion therapy of alloimmunized thrombocytopenic patients. Transplant Proc. 1977;4:1827–8.

    Google Scholar 

  11. Apps R, Qi Y, Carlson JM, Chen H, Gao X, Thomas R, et al. Influence of HLA-C expression level on HIV control. Science. 2013;340:87–91.

    Article  CAS  Google Scholar 

  12. Heim KF, Fleisher TA, Stroncek DF, Holland SM, Gallin JI, Malech HL, et al. The relationship between alloimmunization and posttransfusion granulocyte survival: experience in a chronic granulomatous disease cohort. Transfusion. 2011;51:1154–62.

    Article  CAS  Google Scholar 

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Correspondence to Takaya Yamashita.

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Yamashita, T., Ikegame, K., Ito, F. et al. Effect of low platelet HLA-C expression on donor-specific antibody depletion following platelet transfusion from a corresponding HLA donor. Bone Marrow Transplant 54, 1713–1716 (2019).

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