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Pre-transplant recovery of microbiome diversity without recovery of the original microbiome

Bone Marrow Transplantation volume 54, pages 1115–1117 (2019)Cite this article

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A typical treatment path for many patients with acute leukemia (AL) includes multiple rounds of chemotherapy followed by allogeneic hematopoietic cell transplantation (allo-HCT). Extensive antibiotic exposure, prolonged and repeated healthcare facility contact, nutritional changes, and gut barrier damage in these patients result in major disruptions in the gut microbial communities [1, 2]. Gut dysbiosis has been associated with adverse HCT outcomes including infection [3,4,5], graft-versus-host disease [6, 7], and mortality [8,9,10].

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References

  1. Shono Y, van den Brink MRM. Gut microbiota injury in allogeneic haematopoietic stem cell transplantation. Nat Rev Cancer. 2018;18:283–95.

    Article  CAS  Google Scholar 

  2. Andermann T, Peled J, Ho C, Reddy P, Riches M, Storb R, et al. Microbiome-host interactions in hematopoietic stem cell transplant recipients. Biol Blood Marrow Transplant. 2018. https://doi.org/10.1016/j.bbmt.2018.02.009.

    Article  Google Scholar 

  3. Ubeda C, Taur Y, Jenq RR, Equinda MJ, Son T, Samstein M, et al. Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans. J Clin Invest. 2010;120:4332–41.

    Article  CAS  Google Scholar 

  4. Taur Y, Xavier JB, Lipuma L, Ubeda C, Goldberg J, Gobourne A, et al. Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis. 2012;55:905–14.

    Article  CAS  Google Scholar 

  5. Haak BW, Littmann ER, Chaubard J-L, Pickard AJ, Fontana E, Adhi F, et al. Impact of gut colonization with butyrate producing microbiota on respiratory viral infection following allo-HCT. Blood. 2018;131:blood-2018-01-828996.

    Article  Google Scholar 

  6. Mathewson ND, Jenq R, Mathew AV, Koenigsknecht M, Hanash A, Toubai T, et al. Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease. Nat Immunol. 2016;17:505–13.

    Article  CAS  Google Scholar 

  7. Jenq RR, Taur Y, Devlin SM, Ponce DM, Goldberg JD, Ahr KF, et al. Intestinal blautia is associated with reduced death from graft-versus-host disease. Biol Blood Marrow Transplant. 2015;21:1373–83.

    Article  Google Scholar 

  8. Weber D, Jenq RR, Peled JU, Taur Y, Hiergeist A, Koestler J, et al. Microbiota disruption induced by early use of broad-spectrum antibiotics is an independent risk factor of outcome after allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2017;23:845–52.

    Article  CAS  Google Scholar 

  9. Shono Y, Docampo MD, Peled JU, Perobelli SM, Velardi E, Tsai JJ, et al. Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice. Sci Transl Med. 2016;8:339ra71–339ra71.

    Article  Google Scholar 

  10. Taur Y, Jenq RR, Perales M-A, Littmann ER, Morjaria S, Ling L, et al. The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation. Blood. 2014;124:1174–82.

    Article  CAS  Google Scholar 

  11. Shannon CE, Weaver W. The mathematical theory of communication. Urbana, IL: The University of Illinois Press; 1949.

    Google Scholar 

  12. Dethlefsen L, Relman DA. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc Natl Acad Sci. 2011;108:4554–61.

    Article  CAS  Google Scholar 

  13. Costello EK, Stagaman K, Dethlefsen L, Bohannan BJM, Relman DA. The application of ecological theory toward anunderstanding of the human microbiome. Science. 2012;336:1255–62.

    Article  CAS  Google Scholar 

  14. Paine RT, Tegner MJ, Johnson EA. Compounded perturbations yield ecological surprises. Ecosystems. 1998;1:535–45.

    Article  Google Scholar 

  15. Bray JR, Curtis JT. An ordination of the upland forest communities of southern Wisconsin. Ecol Monogr. 1957;27:325–49.

    Article  Google Scholar 

Download references

Acknowledgements

A University of Minnesota Medical School Innovation grant (to AR), a University of Minnesota Foundation grant (to AR), and funding from Achieving Cures Together and Hubbard Foundation supported this research. We thank Markas Welke, Andrea Hoeschen and Kevin Olson for coordinating sample collections. Sequence data were processed and analyzed using the resources of the Minnesota Supercomputing Institute.

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Authors and Affiliations

  1. Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA

    Armin Rashidi, Shernan G. Holtan & Daniel J. Weisdorf

  2. Department of Surgery, University of Minnesota, Minneapolis, MN, USA

    Thomas Kaiser & Christopher Staley

  3. BioTechnology Institute, University of Minnesota, St. Paul, MN, USA

    Thomas Kaiser, Alexander Khoruts & Christopher Staley

  4. Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Minnesota, Minneapolis, MN, USA

    Alexander Khoruts

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  1. Armin Rashidi
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Correspondence to Armin Rashidi.

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Rashidi, A., Kaiser, T., Holtan, S.G. et al. Pre-transplant recovery of microbiome diversity without recovery of the original microbiome. Bone Marrow Transplant 54, 1115–1117 (2019). https://doi.org/10.1038/s41409-018-0414-z

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