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Vitamin D: is it important in haematopoietic stem cell transplantation? A review

Bone Marrow Transplantation volume 54, pages 810–820 (2019)Cite this article

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Abstract

Vitamin D has effects on several body systems, from well-established role in bone metabolism to emerging effects on the immune system. Increasing evidence supports an immunomodulatory effect including inhibition of the pro-inflammatory lymphocyte subsets while enhancing their anti-inflammatory counterpart, in favour of a more tolerogenic status. Vitamin D deficiency is increasingly recognised in association with autoimmune and inflammatory diseases, also with evidence from the field of asthma where vitamin D supplementation may overcome steroid resistance. In the HSCT setting, vitamin D deficiency has been variably associated with increased complications, including graft-versus-host disease (GvHD), with a potential impact on survival outcomes. In this review we provide an overview and critical appraisal of the current literature of the role of vitamin D (and its deficiency) in relation to immunity in both allogeneic and autologous HSCT settings. We conclude that the evidence base is mixed, but a greater understanding of the role of vitamin D in relation to immune reconstitution following HSCT is warranted. Given its potential benefits, its inexpensive cost and favourable side effect profile, consideration of vitamin D levels and its supplementation could be easily incorporated into prospective studies in GvHD, including clinical trials of novel therapeutics, supportive care and biomarkers.

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Acknowledgements

JRS is currently undertaking a fellowship supported by the Anthony Nolan Research Institute.

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Authors and Affiliations

  1. Anthony Nolan Research Institute, Royal Free Hospital, University College London, London, UK

    Jose Ros-Soto, Chloe Anthias & Alejandro Madrigal

  2. Department of Haemato-Oncology, The Royal Marsden Hospital, Sutton, UK

    Chloe Anthias

  3. Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, University of Sheffield, Sheffield, and University College London, London, UK

    John A. Snowden

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Correspondence to Jose Ros-Soto.

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This review has been carried out as part of a fellowship supported by the Anthony Nolan Research Institute. JRS is currently undertaking a fellowship supported by the Anthony Nolan Research Institute. The remaining authors declare that they have no conflict of interest.

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Ros-Soto, J., Anthias, C., Madrigal, A. et al. Vitamin D: is it important in haematopoietic stem cell transplantation? A review. Bone Marrow Transplant 54, 810–820 (2019). https://doi.org/10.1038/s41409-018-0377-0

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  • DOI: https://doi.org/10.1038/s41409-018-0377-0

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