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Not so crystal clear: observations from a case of crystalline arthritis with cytokine release syndrome (CRS) after chimeric antigen receptor (CAR)-T cell therapy

Bone Marrow Transplantation volume 54, pages 632–634 (2019)Cite this article

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As the use of effector T-cell immunotherapy for the treatment of both solid and non-solid malignancy expands, clinicians across all medical specialties are observing an increased incidence of rheumatic and autoimmune complications. Immune-related adverse events (IRAEs) have been well-described with the use of CTLA-4, PD-1, and PDL-1 inhibitors; however, such organ-specific immune-related toxicities have not been widely reported with chimeric antigen receptor (CAR)-T cell therapy. Here, we describe a case of crystalline arthritis observed in the context of cytokine release syndrome (CRS) after CAR-T cell therapy, and we discuss potential mechanistic links.

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Authors and Affiliations

  1. Division of Rheumatology, University of Washington, Seattle, WA, USA

    Sarah H. Chung & Grant Hughes

  2. CLL Society, Claremont, CA, USA

    Brian Koffman

  3. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Cameron J. Turtle, David G. Maloney & Utkarsh H. Acharya

  4. Division of Medical Oncology, University of Washington, Seattle, WA, USA

    Cameron J. Turtle, David G. Maloney & Utkarsh H. Acharya

  5. Division of Cellular Therapy in Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA

    Utkarsh H. Acharya

Authors
  1. Sarah H. Chung
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  2. Grant Hughes
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  3. Brian Koffman
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  4. Cameron J. Turtle
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  5. David G. Maloney
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  6. Utkarsh H. Acharya
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Corresponding author

Correspondence to Sarah H. Chung.

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Chung, S.H., Hughes, G., Koffman, B. et al. Not so crystal clear: observations from a case of crystalline arthritis with cytokine release syndrome (CRS) after chimeric antigen receptor (CAR)-T cell therapy. Bone Marrow Transplant 54, 632–634 (2019). https://doi.org/10.1038/s41409-018-0357-4

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  • DOI: https://doi.org/10.1038/s41409-018-0357-4

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