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A dynamical systems perspective on chimeric antigen receptor T-cell dosing

Bone Marrow Transplantation volume 54, pages 485–489 (2019)Cite this article

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Abstract

Chimeric antigen receptor T cells (CAR T cells) are dosed similarly to donor lymphocyte infusions following hematopoietic cell transplantation. However, the mechanism driving proliferation in CAR T cells is distinct from conventional T cells. As such there are quantitative differences in the antigen response of these engineered cells when compared with conventional T cells. In this perspective paper the logistic equation of growth is used to develop a mathematical basis for understanding the difference between CAR T cell and conventional T cell response to antigen burden.

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Acknowledgements

AAT was supported, in part, by research funding from the NIH-NCI Cancer Center Support Grant (P30-CA016059; PI: Gordon Ginder, MD).

Author contributions

AAT, developed the idea and wrote the paper. AC, developed the idea and wrote the paper. JZ, developed the idea and wrote the paper. JR, developed the idea and wrote the paper. SKH, developed the idea and wrote the paper.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Bone Marrow Transplant Program, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA

    Amir A. Toor

  2. Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA

    Alden Chesney

  3. Department of Radiology, Virginia Commonwealth University, Richmond, VA, USA

    Jamal Zweit

  4. Department of Physics, Virginia Commonwealth University, Richmond, VA, USA

    Jason Reed

  5. Division of Hematology, Dept. of Medicine, Mayo Clinic, Rochester, MN, USA

    Shahrukh K. Hashmi

  6. Dept. Of Stem Cell Transplant, Oncology Center, KFSHRC, Riyadh, Saudi Arabia

    Shahrukh K. Hashmi

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  1. Amir A. Toor
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  2. Alden Chesney
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  4. Jason Reed
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Correspondence to Amir A. Toor.

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Toor, A.A., Chesney, A., Zweit, J. et al. A dynamical systems perspective on chimeric antigen receptor T-cell dosing. Bone Marrow Transplant 54, 485–489 (2019). https://doi.org/10.1038/s41409-018-0329-8

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