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High-dose chemotherapy and autologous stem cell transplantation in enteropathy-associated and other aggressive T-cell lymphomas: a UK NCRI/Cancer Research UK Phase II Study

Bone Marrow Transplantation volume 54, pages 465–468 (2019)Cite this article

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A Correction to this article was published on 12 March 2019

This article has been updated

Outcomes for patients with peripheral T-cell lymphoma (PTCL) are generally poor with 35–40% 5-year survival using CHOP-like chemotherapy. Addition of other agents to cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) has not consistently improved outcomes and can cause excess toxicity [1, 2]; new approaches are urgently needed. Favourable outcomes have been achieved with autologous stem-cell transplant consolidation (ASCT) in some settings with long-term survival rates exceeding 50%, particularly for those transplanted in first complete remission [3].

EATL is a rare form of T-cell lymphoma with an incidence of 0.1/100,000 per year in Western Europe [4]. Enteropathy-associated T-cell lymphoma (EATL) poses a number of diagnostic and therapeutic challenges, as patients frequently present with poor performance status, malnutrition and acute abdominal complications. There is no established standard of care and outcomes are inferior to other T-cell lymphomas with 5-year failure free survival of < 5% [5,6,7]. We have previously reported the use of intensive chemotherapy followed by ASCT in a retrospective population-based study of patients with EATL [4]. These favourable results encouraged us to prospectively assess the feasibility of this approach in a multi-centre setting for aggressive T-cell lymphoma.

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Fig. 1

Change history

  • 06 March 2019

    In the original version of this manuscript, the mention of ‘ifosfamide 1500mg/m2 days 1-3’ should in fact read ‘ifosfamide 1500mg/m2 bd days 1-3’. This has now been updated in the original version of the manuscript.

  • 12 March 2019

    In the original version of this article, the mention of ‘ifosfamide 1500 mg/m2 days 1–3’ should, in fact, read ‘ifosfamide 1500 mg/m2 bd days 1–3’. This has now been updated in the original version of the article.

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Acknowledgements

Conduct of this study was funded by Cancer Research UK (grant reference: C12372/A4755). This trial is registered at clinicaltrials.gov (NCT00669812) and EudraCT (2005-003906-27).

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Authors and Affiliations

  1. Cancer Research UK and University College London Cancer Trials Centre, London, UK

    Elizabeth H. Phillips, Andre Lopes, Humra Chadwick, Laura Clifton-Hadley, Paul Smith, Anthony Lawrie & Nick Chadwick

  2. Department of Haematology, Freeman Hospital, Newcastle Upon Tyne, UK

    Michelle M. Lannon, Gail Jones & Anne L. Lennard

  3. South Tyneside District Hospital, South Shields, UK

    Michal Sieniawski

  4. Cancer Research UK Centre, Cancer Sciences Unit, University of Southampton, Faculty of Medicine, Southampton, UK

    Andrew Davies

  5. Department of Cellular Pathology, Royal Victoria Infirmary, Newcastle Upon Tyne, UK

    Katrina Wood

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Phillips, E.H., Lannon, M.M., Lopes, A. et al. High-dose chemotherapy and autologous stem cell transplantation in enteropathy-associated and other aggressive T-cell lymphomas: a UK NCRI/Cancer Research UK Phase II Study. Bone Marrow Transplant 54, 465–468 (2019). https://doi.org/10.1038/s41409-018-0294-2

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