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Immune monitoring in allogeneic hematopoietic stem cell transplant recipients: a survey from the EBMT-CTIWP

Bone Marrow Transplantation volume 53, pages 1201–1205 (2018)Cite this article

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Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective curative treatment for several high-risk hematological malignancies (high-risk leukemia, myelodysplastic syndromes, advanced myeloproliferative disorders, high-risk lymphomas, and multiple myeloma). Sixty years after the first clinical application, it is currently applied in more than 15,000 patients per year in Europe [1].

The post-transplant immune restoration is one of the main factors influencing the clinical outcome of allo-HSCT. Even though fast hematopoietic engraftment and chimerism can usually be documented, severe immune defects commonly occur early after transplant and might persist for several months. The kinetics and quality of immune reconstitution depend on several pre and post-transplant variables. Well established pre-transplant parameters include the age of the recipient, diagnosis, degree of HLA antigen mismatches and non-HLA antigens, origin and manipulation of the graft, conditioning regimen, infectious serostatus of the donor and recipient. Several clinical parameters, including infectious complications, disease relapse, occurrence of graft-versus-host disease (GvHD), impaired thymic function, contribute to post-transplant immuno-incompetence [2,3,4,5,6,7].

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Acknowledgements

This work was supported by the EBMT and CTIWP. M. A. Bekadja, P. J. Shaw, P. Cannell, S. Matthes-Martin, J. Maertens, E. Faber, P. Jindra, R. Formankova, M. Itälä-Remes, M. Itala-Remes, H. Labussiere-Wallet, N. Milpied, D. Olive, J. H. Dalle, P.S. Rohrlich, N. Fegueux, D. Desmier, C. Rössig, M. Stelljes, E. Jost, N. Kröger, G. Stuhler, L. P. Müller, P. Bader, H. Einsele, A. Anagnostopoulos, A. Spyridonidis, G. Kriván, R. Ram, M. Bitan, A. Nagler, D. Russo, P. Chiusolo, A. Olivieri, A. Biondi, E. Lanino, F. Ciceri, A. Bertaina, B. Bruno, G. Saporiti, P. Corradini, A. Velardi, L. Castagna, F. Patriarca, W. Arcese, F. Preijers, A. Lange, M. Abecasis, V. Savchenko, M. A. Diaz, A. Sampol, J. Gayoso, I. Garcia Cadenas, J. R. Cabrera Marin, R. Parody Porras, E. López Granados, C. Ferra, G. Orti, K. Carlson, P. Ljungman, S. Lenhoff, J. Passweg, T. Güngör, T. Ben Othman, Y. Koc, D. Uckan-Cetinkaya, Z.U. Ozkurt, H. Ozdogu, G. Gurman, V. Uygun, A. Unal, G. McQuaker, K. Orchard, K. Patrick, J. Apperley, M. Gilleece.

Author contributions

R.G., S.M.V., C.C. and C.B. designed the study and analyzed the data. All authors contributed to data collection. R.G. and C.B. wrote the manuscript. All authors have approved the final version of the manuscript.

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Authors and Affiliations

  1. Unit of Hematology and BMT, IRCCS San Raffaele Scientific Institute, Milano, Italy

    Raffaella Greco, Fabio Ciceri & Jacopo Peccatori

  2. Vita-Salute San Raffaele University, Milano, Italy

    Raffaella Greco, Fabio Ciceri, Attilio Bondanza & Chiara Bonini

  3. Experimental Hematology Unit, San Raffaele Scientific Institute, Milano, Italy

    Maddalena Noviello, Giacomo Oliveira & Chiara Bonini

  4. Innovative Immunotherapies Unit, San Raffaele Scientific Institute, Milan, Italy

    Attilio Bondanza

  5. Unit of Immunogenetics, Leukemia Genomics and Immunobiology, San Raffaele Scientific Institute, Milano, Italy

    Luca Vago

  6. Università degli Studi di Milano, Milano, Italy

    Nicoletta Cieri

  7. Hospital Saint Antoine and Hôpital Saint Louis, Paris, France

    Annalisa Ruggeri

  8. Institute of Cellular Therapeutics, Hannover Medical School, Hannover, Germany

    Ulrike Koehl

  9. Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany

    Katharina Fleischhauer

  10. Brazil and British Bone Marrow Registry-BBMR, Hospital Sirio-Libanes, São Paulo, Brazil

    Vanderson Rocha

  11. Division of Cancer Studies, King’s College London, London, UK

    Francesco Dazzi

  12. Department of Medical Statistics and Bioinformatics, Leiden, The Netherlands

    Steffie Maria van der Werf, Dirk-Jan Eikema & Sofie Rosanne Terwel

  13. Department of Hematology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands

    Jürgen Kuball

  14. Laboratoire d’Immunologie et Histocompatibilité, Hôpital Saint-Louis, APHP, INSERM U1160, Université Paris Diderot, Paris, France

    Antoine Toubert

  15. Institut Paoli-Calmettes, Centre de Lutte Contre le Cancer; Centre d’Investigations Cliniques en Biothérapie, Université d’Aix-Marseille, Inserm CBT 1409, Marseille, France

    Christian Chabannon

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on behalf of EBMT Cellular Therapy and Immunobiology Working Party (CTIWP)

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Correspondence to Chiara Bonini.

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The authors declare that they have no conflict of interest.

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Greco, R., Ciceri, F., Noviello, M. et al. Immune monitoring in allogeneic hematopoietic stem cell transplant recipients: a survey from the EBMT-CTIWP. Bone Marrow Transplant 53, 1201–1205 (2018). https://doi.org/10.1038/s41409-018-0167-8

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  • DOI: https://doi.org/10.1038/s41409-018-0167-8

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