This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Passweg JR, Baldomero H, Bader P, Bonini C, Duarte RF, Dufour C, et al. Use of haploidentical stem cell transplantation continues to increase: the 2015 European Society for Blood and Marrow Transplant activity survey report. Bone Marrow Transplant. 2017;52:811–7.
Bosch M, Khan FM, Storek J. Immune reconstitution after hematopoietic cell transplantation. Curr Opin Hematol. 2012;19:324–35.
van Den Brink M, Leen AM, Baird K, Merchant M, Mackall C, Bollard CM. Enhancing immune reconstitution: from bench to bedside. Biol Blood Marrow Transplant. 2013;19:S79–83. 1 Suppl
Seggewiss R, Einsele H. Immune reconstitution after allogeneic transplantation and expanding options for immunomodulation: an update. Blood. 2010;115:3861–8.
Abrahamsen IW, Somme S, Heldal D, Egeland T, Kvale D, Tjonnfjord GE. Immune reconstitution after allogeneic stem cell transplantation: the impact of stem cell source and graft-versus-host disease. Haematologica. 2005;90:86–93.
Geddes M, Storek J. Immune reconstitution following hematopoietic stem-cell transplantation. Best Pract Res Clin Haematol. 2007;20:329–48.
Toubert A, Glauzy S, Douay C, Clave E. Thymus and immune reconstitution after allogeneic hematopoietic stem cell transplantation in humans: never say never again. Tissue Antigens. 2012;79:83–9.
Mussetti A, Greco R, Peccatori J, Corradini P. Post-transplant cyclophosphamide, a promising anti-graft versus host disease prophylaxis: where do we stand? Expert Rev Hematol. 2017;10:479–92.
Luznik L, O’Donnell PV, Symons HJ, Chen AR, Leffell MS, Zahurak M, et al. HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant. 2008;14:641–50.
Bleakley M, Turtle CJ, Riddell SR. Augmentation of anti-tumor immunity by adoptive T-cell transfer after allogeneic hematopoietic stem cell transplantation. Expert Rev Hematol. 2012;5:409–25.
Locatelli F, Merli P, Pagliara D, Li Pira G, Falco M, Pende D, et al. Outcome of children with acute leukemia given HLA-haploidentical HSCT after alphabeta T-cell and B-cell depletion. Blood. 2017;130:677–85.
Perales MA, van den Brink MR. Immune recovery after allogeneic hematopoietic stem cell transplantation: is it time to revisit how patients are monitored? Biol Blood Marrow Transplant. 2012;18:1617–9.
Forcina A, Noviello M, Carbone MR, Bonini C, Bondanza A. Predicting the clinical outcome of allogeneic hematopoietic stem cell transplantation: the long and winding road toward validated immune biomarkers. Front Immunol. 2013;4:71.
Cieri N, Oliveira G, Greco R, Forcato M, Taccioli C, Cianciotti B, et al. Generation of human memory stem T cells after haploidentical T-replete hematopoietic stem cell transplantation. Blood. 2015;125:2865–74.
Oliveira G, Ruggiero E, Stanghellini MT, Cieri N, D’Agostino M, Fronza R, et al. Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory. Sci Transl Med. 2015;7:317ra198.
Acknowledgements
This work was supported by the EBMT and CTIWP. M. A. Bekadja, P. J. Shaw, P. Cannell, S. Matthes-Martin, J. Maertens, E. Faber, P. Jindra, R. Formankova, M. Itälä-Remes, M. Itala-Remes, H. Labussiere-Wallet, N. Milpied, D. Olive, J. H. Dalle, P.S. Rohrlich, N. Fegueux, D. Desmier, C. Rössig, M. Stelljes, E. Jost, N. Kröger, G. Stuhler, L. P. Müller, P. Bader, H. Einsele, A. Anagnostopoulos, A. Spyridonidis, G. Kriván, R. Ram, M. Bitan, A. Nagler, D. Russo, P. Chiusolo, A. Olivieri, A. Biondi, E. Lanino, F. Ciceri, A. Bertaina, B. Bruno, G. Saporiti, P. Corradini, A. Velardi, L. Castagna, F. Patriarca, W. Arcese, F. Preijers, A. Lange, M. Abecasis, V. Savchenko, M. A. Diaz, A. Sampol, J. Gayoso, I. Garcia Cadenas, J. R. Cabrera Marin, R. Parody Porras, E. López Granados, C. Ferra, G. Orti, K. Carlson, P. Ljungman, S. Lenhoff, J. Passweg, T. Güngör, T. Ben Othman, Y. Koc, D. Uckan-Cetinkaya, Z.U. Ozkurt, H. Ozdogu, G. Gurman, V. Uygun, A. Unal, G. McQuaker, K. Orchard, K. Patrick, J. Apperley, M. Gilleece.
Author contributions
R.G., S.M.V., C.C. and C.B. designed the study and analyzed the data. All authors contributed to data collection. R.G. and C.B. wrote the manuscript. All authors have approved the final version of the manuscript.
Author information
Authors and Affiliations
Consortia
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Electronic supplementary material
Rights and permissions
About this article
Cite this article
Greco, R., Ciceri, F., Noviello, M. et al. Immune monitoring in allogeneic hematopoietic stem cell transplant recipients: a survey from the EBMT-CTIWP. Bone Marrow Transplant 53, 1201–1205 (2018). https://doi.org/10.1038/s41409-018-0167-8
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41409-018-0167-8
This article is cited by
-
Dynamics of polyclonal immuno-reconstitution after allogeneic transplant with post-transplant cyclophosphamide and letermovir
Bone Marrow Transplantation (2023)
-
Monitoring for virus-specific T-cell responses and viremia in allogeneic HSCT recipients: a survey from the EBMT Cellular Therapy & Immunobiology Working Party
Bone Marrow Transplantation (2023)