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High transplant-related mortality associated with haematopoietic stem cell transplantation for paediatric therapy-related acute myeloid leukaemia (t-AML). A study on behalf of the United Kingdom Paediatric Blood and Bone Marrow Transplant Group

Bone Marrow Transplantation volume 53, pages 1165–1169 (2018)Cite this article

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Abstract

Paediatric therapy-related acute myeloid leukaemia (t-AML) is rare and the outcome is poor. While allogeneic haematopoietic stem cell transplantation (HSCT) is generally the accepted modality of treatment, data regarding salvage chemotherapy, remission induction, conditioning regimens, transplant-related mortality and outcome is scarce. Between 2000 and2016, 36 children with t-AML were treated in seven UK paediatric HSCT centres. The most common salvage protocol for remission induction was FLAG with or without idarubicin and 28 patients were in complete morphological remission prior to BMT. Only 12 patients survived (33%). Transplant-related mortality (TRM) was the leading cause of death.

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Acknowledgements

We are indebted to the patients and their families as well as to the nursing, medical staff in all UK Paediatric HSCT centres for their excellent patient care and continuing support.

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Authors and Affiliations

  1. Department of Haematology and Oncology, Royal Hospital for Children, Bristol, UK

    Adam Gassas, Ponni Sivaprakasam, Michelle Cummins & Patricia Breslin

  2. Department of Haematology and Oncology, Sheffield Children’s Hospital, Sheffield, UK

    Katharine Patrick

  3. Children’s Haemopoietic Stem Cell Transplant Unit, Great North Children’s Hospital, Newcastle upon Tyne, UK

    Mary Slatter, Roderick Skinner & Geof Shenton

  4. Department of Haematology and Oncology, Royal Hospital for Children, Glasgow, UK

    Brenda Gibson

  5. Department of Haematology and Oncology, Birmingham Children’s Hospital, Birmingham, UK

    Sarah Lawson

  6. Department of Haematology and Oncology, Royal Marsden Hospital, Sutton, UK

    Toni Petterson & Michael Potter

  7. Department of Haematology and Oncology, Leeds Teaching Hospital, Leeds, UK

    Beki James

  8. Department of Haematology and Oncology, University College of London, London, UK

    Rachael Hough

  9. Department of Haematology and Oncology, Royal Manchester Children’s Hospital, Manchester, UK

    Prashant Hiwarkar & Robert Wynn

  10. Department of Haematology and Oncology, Great Ormond Street Hospital for Children, London, UK

    Ajay Vora, Paul Veys & Persis Amrolia

  11. Department of Haematology and Oncology, St Marys Hospital, Imperial College, London, UK

    Josu De La Fuente

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  1. Adam Gassas
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  2. Ponni Sivaprakasam
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  9. Brenda Gibson
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  10. Sarah Lawson
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  11. Toni Petterson
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  13. Beki James
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  14. Rachael Hough
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  15. Prashant Hiwarkar
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  16. Ajay Vora
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  17. Paul Veys
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  18. Josu De La Fuente
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  19. Robert Wynn
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  20. Persis Amrolia
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Correspondence to Adam Gassas.

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The authors declare that they have no conflict of interest.

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Gassas, A., Sivaprakasam, P., Cummins, M. et al. High transplant-related mortality associated with haematopoietic stem cell transplantation for paediatric therapy-related acute myeloid leukaemia (t-AML). A study on behalf of the United Kingdom Paediatric Blood and Bone Marrow Transplant Group. Bone Marrow Transplant 53, 1165–1169 (2018). https://doi.org/10.1038/s41409-018-0157-x

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  • DOI: https://doi.org/10.1038/s41409-018-0157-x

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