Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Pretransplant comprehensive geriatric assessment in hematopoietic cell transplantation: a single center experience

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Giralt SA. Hematopoietic cell transplantation for older adults. In: Korc-Grodzicki B, Tew WP, editors. ch 25. Handbook of geriatric oncology; Demos Medical Publishing, New York, NY, USA. 2017; p. 241–54.

  2. Deeg HJ, Sandmaier BM. Who is fit for allogeneic transplantation? Blood. 2010;116:4762–70.

    Article  CAS  Google Scholar 

  3. Sorror ML, Storb RF, Sandmaier BM, Maziarz RT, Pulsipher MA, Maris MB, et al. Comorbidity-age index: a clinical measure of biologic age before allogeneic hematopoietic cell transplantation. J Clin Oncol. 2014;32:3249–56.

    Article  Google Scholar 

  4. Barba P, Ratan R, Cho C, Ceberio I, Hilden P, Devlin SM, et al. Hematopoietic cell transplantation comorbidity index predicts outcomes in patients with acute myeloid leukemia and myelodysplastic syndromes receiving CD34+ selected grafts for allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2017;23:67–74.

    Article  Google Scholar 

  5. Lin RJ, Behera M, Diefenbach CS, Flowers CR. The role of anthracycline and comprehensive geriatric assessment for elderly patients with diffuse large B-cell lymphoma. Blood. 2017;130:2180–5.

    Article  CAS  Google Scholar 

  6. Hamaker ME, Prins MC, Stauder R. The relevance of a geriatric assessment for elderly patients with a haematological malignancy – a systematic review. Leuk Res. 2014;38:275–83.

    Article  CAS  Google Scholar 

  7. Muffly LS, Kocherginsky M, Stock W, Chu Q, Bishop MR, Godley LA, et al. Geriatric assessment to predict survival in older allogeneic hematopoietic cell transplantation recipients. Haematologica. 2014;99:1373–9.

    Article  Google Scholar 

  8. Wildiers H, Heeren P, Puts M, Topinkova E, Janssen-Heijnen ML, Extermann M, et al. International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer. J Clin Oncol. 2014;32:2595–603.

    Article  Google Scholar 

  9. Shahrokni A, Tin A, Downey RJ, Strong V, Mahmoudzadeh S, Boparai MK, et al. Electronic rapid fitness assessment: a novel tool for preoperative evaluation of the geriatric oncology patient. J Natl Compr Canc Netw. 2017;15:172–9.

    Article  Google Scholar 

  10. Kosuri S, Adrianzen Herrera D, Scordo M, Shah GL, Cho C, Devlin SM, et al. The impact of toxicities on first-year outcomes after ex vivo CD34+-selected allogeneic hematopoietic cell transplantation in adults with hematologic malignancies. Biol Blood Marrow Transplant. 2017;23:2004–11.

    Article  CAS  Google Scholar 

  11. Shah GL, Scordo M, Kosuri S, Herrera DA, Cho C, Devlin SM, et al. Impact of toxicity on survival for older adult patients after CD34+ selected allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2017;24:142–9.

    Article  Google Scholar 

  12. Scordo M, Shah GL, Kosuri S, Herrera DA, Cho C, Devlin SM, et al. Effects of late toxicities on outcomes in long-term survivors of ex-vivo CD34+-selected allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2017;24:133–41.

    Article  Google Scholar 

  13. By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American Geriatrics Society 2015 Updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2015;63:2227–46.

    Article  Google Scholar 

  14. Tamari R, Chung SS, Papadopoulos EB, Jakubowski AA, Hilden P, Devlin SM, et al. CD34-selected hematopoietic stem cell transplants conditioned with myeloablative regimens and antithymocyte globulin for advanced myelodysplastic syndrome: limited graft-versus-host disease without increased relapse. Biol Blood Marrow Transplant. 2015;21:2106–14.

    Article  Google Scholar 

  15. Muffly LS, Boulukos M, Swanson K, Kocherginsky M, Cerro PD, Schroeder L, et al. Pilot study of comprehensive geriatric assessment (CGA) in allogeneic transplant: CGA captures a high prevalence of vulnerabilities in older transplant recipients. Biol Blood Marrow Transplant. 2013;19:429–34.

    Article  Google Scholar 

  16. Holmes HM, Des Bordes JK, Kebriaei P, Yennu S, Champlin RE, Giralt S, et al. Optimal screening for geriatric assessment in older allogeneic hematopoietic cell transplantation candidates. J Geriatr Oncol. 2014;5:422–30.

    Article  Google Scholar 

  17. Olin RL, Andreadis C, Martin TG, Wolf JL, Kaplan LD, Ai W, et al. Comprehensive geriatric assessment identifies significant functional impairments in older hematopoietic cell transplant recipients. Biol Blood Marrow Transplant. 2014;20:S65–S66.

    Article  Google Scholar 

  18. Jakubowski AA, Petrlik E, Maloy M, Hilden P, Papadopoulos E, Young JW, et al. T cell depletion as an alternative approach for patients 55 years or older undergoing allogeneic stem cell transplantation as curative therapy for hematologic malignancies. Biol Blood Marrow Transplant. 2017;23:1685–94.

    Article  Google Scholar 

  19. Rosko A, Artz A. Aging: treating the older patient. Biol Blood Marrow Transplant. 2017;23:193–200.

    Article  Google Scholar 

  20. Ferrell BR, Temel JS, Temin S, Alesi ER, Balboni TA, Basch EM, et al. Integration of palliative care into standard oncology care: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol. 2017;35:96–112.

    Article  Google Scholar 

Download references

Acknowledgements

This research was supported in part by the New York State Empire Clinical Research Investigator Program (ECRIP) and the NIH/NCI Cancer Center Support Grant P30 CA008748. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Richard J. Lin or Sergio A. Giralt.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lin, R.J., Shahrokni, A., Dahi, P.B. et al. Pretransplant comprehensive geriatric assessment in hematopoietic cell transplantation: a single center experience. Bone Marrow Transplant 53, 1184–1187 (2018). https://doi.org/10.1038/s41409-018-0151-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41409-018-0151-3

This article is cited by

Search

Quick links