Table 3 Test characteristics of the tear function tests when used alone for diagnosis of dry eye disease or ocular GVHD by NIH and ICCGVHD criteria, n = 96 patients (worst eye)

From: Ocular findings and ocular graft-versus-host disease after allogeneic stem cell transplantation without total body irradiation

Single test Dry eye disease (DED) Ocular GVHD by ICCGVHD criteria Ocular GVHD by NIH criteriaa
  Patients with DED (n = 52) /without DED (n = 44) Sensitivity/specificity (%) Negative/positive predictive value (%) Patients with oGVHD (n = 23) / without oGVHD (n = 73) Sensitivity/ specificity (%) Negative/positive predictive value (%) Patients with oGVHD (n = 42) /without oGVHD (n = 51) Sensitivity/specificity (%) Negative/positive predictive value (%)
Schirmer’s test, ≤ 5 mm 39a/8 80/82 78/83 19a/20 86/72 94/49 34a,b/0b 81/100 86/ 100
Tear break-up time, ≤ 5 seconds 35/9 67/80 67/80 12/29 55/60 81/29 27/15 64/71 71/ 64
Ocular Surface Disease Index, ≥ 13 23/1 44/98 60/96 15/9 65/88 89/63 13/9 31/82 59 /59
Corneal staining, ≥ grade 1 28/4 54/91 63/88 19/14 83/81 94/58 26/5 62/90 74 /84
Conjunctival inflammation, ≥ grade 1 4/0 8/100 48/100 4/0 17/100 79/100 3/0 7/100 57/ 100
Tear film osmolarity, > 308 mOsmol/l 32c/27 62/39 53/54 10c/35 45/52 84/22 28c/30 67/41 68/ 48
  1. cGVHD chronic graft-vs-host disease, DED dry eye disease, ICCGVHD International Chronic Ocular Graft-vs-Host-Disease Consensus Group, NIH National Institutes of Health, oGVHD ocular graft-vs-host disease
  2. aSchirmer’s test not possible in three patients (pain)
  3. bMean Schirmer of both eyes
  4. cTear film osmolarity missing in five patients (technical problem/patient lacking tear film)