Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Donor HSCs with a preexisting ASXL1-mutation led to the development of FLT3-ITD positive AML in the donor and FLT3-ITD negative AML in the recipient after unrelated transplant

This is a preview of subscription content, access via your institution

Access options

Buy this article

Purchase on Springer Link

Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

Fig. 1
Fig. 2

References

  1. Acuna-Hidalgo R, Sengul H, Steehouwer M, van de Vorst M, Vermeulen SH, Kiemeney L, et al. Ultra-sensitive sequencing identifies high prevalence of clonal hematopoiesis-associated mutations throughout adult life. Am J Human Genet. 2017;101:50–64. https://doi.org/10.1016/j.ajhg.2017.05.013. e-pub ahead of print 2017/07/04.

    Article  CAS  Google Scholar 

  2. Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, et al. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med. 2014;371:2488–98. https://doi.org/10.1056/NEJMoa1408617.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Khan SS, Singer BD, Vaughan DE. Molecular and physiological manifestations and measurement of aging in humans. Aging Cell. 2017;16:624–33. https://doi.org/10.1111/acel.12601. e-pub ahead of print 2017/05/26.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Wiseman DH. Donor cell leukemia: a review. Biol Blood Marrow Transplant. 2011;17:771–89. https://doi.org/10.1016/j.bbmt.2010.10.010.

    Article  PubMed  Google Scholar 

  5. Gondek LP, Zheng G, Ghiaur G, DeZern AE, Matsui W, Yegnasubramanian S, et al. Donor cell leukemia arising from clonal hematopoiesis after bone marrow transplantation. Leukemia. 2016;30:1916–20. https://doi.org/10.1038/leu.2016.63. e-pub ahead of print 2016/03/16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Hahn CN, Ross DM, Feng J, Beligaswatte A, Hiwase DK, Parker WT, et al. A tale of two siblings: two cases of AML arising from a single pre-leukemic DNMT3A mutant clone. Leukemia. 2015;29:2101–4. https://doi.org/10.1038/leu.2015.67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Wang F, Zhang Y, Chen X, Fang J, Wang M, Teng W, et al. Mutaome analysis including 10 mutated genes in newly diagnosed acute myeloid leukemia patients. J Leuk & Lymphoma. 2015;24:161–4. https://doi.org/10.3760/cma.j.issn.1009-9921.2015.03.009.

    Article  CAS  Google Scholar 

  8. Corces-Zimmerman MR, Majeti R. Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis. Leukemia. 2014;28:2276–82. https://doi.org/10.1038/leu.2014.211.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Shlush LI, Zandi S, Mitchell A, Chen WC, Brandwein JM, Gupta V, et al. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature. 2014;506:328–33. https://doi.org/10.1038/nature13038.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Bullinger L, Dohner K, Dohner H. Genomics of acute myeloid leukemia diagnosis and pathways. J Clin Oncol: Off J Am Soc Clin Oncol. 2017;35:934–46. https://doi.org/10.1200/jco.2016.71.2208. e-pub ahead of print 2017/03/16.

    Article  CAS  Google Scholar 

  11. Tomasetti C, Vogelstein B. Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science. 2015;347:78–81. https://doi.org/10.1126/science.1260825.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We thank Dr. Dan L. Longo (Deputy Editor, New England Journal of Medicine) for invaluable guidance in the preparation of the manuscript. This study was partially supported by the National Natural Science Foundation of China (No. 81273259, No. 81471589), the Health Bureau of Henan Province, P.R. China (No. 201201005) and the foundation and frontier research grant of Henan provincial science and technology bureau, P.R. China (No.112300410027, No.142300410078).

Author contributions

ZL performed the clinical research and contributed vital clinical data. HL and FW designed the research, performed research, and contributed analyzed data. YZ performed the clinical research and contributed vital clinical data. DK, MS, HAWA, LH performed clinical research and contributed vital clinical data. MW performed research and contributed vital samples of donated PBSC. MC, WJM, and KS designed the research, analyzed the data, and wrote the paper.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kai Sun.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liu, Z., Liu, H., Shi, M. et al. Donor HSCs with a preexisting ASXL1-mutation led to the development of FLT3-ITD positive AML in the donor and FLT3-ITD negative AML in the recipient after unrelated transplant. Bone Marrow Transplant 53, 499–502 (2018). https://doi.org/10.1038/s41409-017-0046-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41409-017-0046-8

Search

Quick links