This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
Purchase on Springer Link
Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Acuna-Hidalgo R, Sengul H, Steehouwer M, van de Vorst M, Vermeulen SH, Kiemeney L, et al. Ultra-sensitive sequencing identifies high prevalence of clonal hematopoiesis-associated mutations throughout adult life. Am J Human Genet. 2017;101:50–64. https://doi.org/10.1016/j.ajhg.2017.05.013. e-pub ahead of print 2017/07/04.
Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, et al. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med. 2014;371:2488–98. https://doi.org/10.1056/NEJMoa1408617.
Khan SS, Singer BD, Vaughan DE. Molecular and physiological manifestations and measurement of aging in humans. Aging Cell. 2017;16:624–33. https://doi.org/10.1111/acel.12601. e-pub ahead of print 2017/05/26.
Wiseman DH. Donor cell leukemia: a review. Biol Blood Marrow Transplant. 2011;17:771–89. https://doi.org/10.1016/j.bbmt.2010.10.010.
Gondek LP, Zheng G, Ghiaur G, DeZern AE, Matsui W, Yegnasubramanian S, et al. Donor cell leukemia arising from clonal hematopoiesis after bone marrow transplantation. Leukemia. 2016;30:1916–20. https://doi.org/10.1038/leu.2016.63. e-pub ahead of print 2016/03/16.
Hahn CN, Ross DM, Feng J, Beligaswatte A, Hiwase DK, Parker WT, et al. A tale of two siblings: two cases of AML arising from a single pre-leukemic DNMT3A mutant clone. Leukemia. 2015;29:2101–4. https://doi.org/10.1038/leu.2015.67.
Wang F, Zhang Y, Chen X, Fang J, Wang M, Teng W, et al. Mutaome analysis including 10 mutated genes in newly diagnosed acute myeloid leukemia patients. J Leuk & Lymphoma. 2015;24:161–4. https://doi.org/10.3760/cma.j.issn.1009-9921.2015.03.009.
Corces-Zimmerman MR, Majeti R. Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis. Leukemia. 2014;28:2276–82. https://doi.org/10.1038/leu.2014.211.
Shlush LI, Zandi S, Mitchell A, Chen WC, Brandwein JM, Gupta V, et al. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature. 2014;506:328–33. https://doi.org/10.1038/nature13038.
Bullinger L, Dohner K, Dohner H. Genomics of acute myeloid leukemia diagnosis and pathways. J Clin Oncol: Off J Am Soc Clin Oncol. 2017;35:934–46. https://doi.org/10.1200/jco.2016.71.2208. e-pub ahead of print 2017/03/16.
Tomasetti C, Vogelstein B. Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science. 2015;347:78–81. https://doi.org/10.1126/science.1260825.
Acknowledgements
We thank Dr. Dan L. Longo (Deputy Editor, New England Journal of Medicine) for invaluable guidance in the preparation of the manuscript. This study was partially supported by the National Natural Science Foundation of China (No. 81273259, No. 81471589), the Health Bureau of Henan Province, P.R. China (No. 201201005) and the foundation and frontier research grant of Henan provincial science and technology bureau, P.R. China (No.112300410027, No.142300410078).
Author contributions
ZL performed the clinical research and contributed vital clinical data. HL and FW designed the research, performed research, and contributed analyzed data. YZ performed the clinical research and contributed vital clinical data. DK, MS, HAWA, LH performed clinical research and contributed vital clinical data. MW performed research and contributed vital samples of donated PBSC. MC, WJM, and KS designed the research, analyzed the data, and wrote the paper.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Electronic supplementary material
Rights and permissions
About this article
Cite this article
Liu, Z., Liu, H., Shi, M. et al. Donor HSCs with a preexisting ASXL1-mutation led to the development of FLT3-ITD positive AML in the donor and FLT3-ITD negative AML in the recipient after unrelated transplant. Bone Marrow Transplant 53, 499–502 (2018). https://doi.org/10.1038/s41409-017-0046-8
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41409-017-0046-8