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Access to alternative donor hematopoietic search and transplantation for acute leukemia in different macro-regions of Italy. A GITMO/IBMDR study

Bone Marrow Transplantation volume 53, pages 291–299 (2018)Cite this article

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Abstract

Hematopoietic Stem Cell Transplantation activity levels vary across European countries. No data are available on the homogeneity of access to the transplant procedure for patient with leukaemia, within any European country. We measured homogeneity of the rate of alternative donor search in patients affected by acute leukaemia resident in each Italian region and macro-region during years 2010–2013. A total of 2747 alternative donor searches were studied. Twenty-one percent of all donor searches were made through extra-regional migration. Rate of alternative donor searches varied among the country’s regions and macro-regions. The rate of donor searches was 38% lower in South Italy than in North Italy, and the rate of alternative donor transplantations performed was 45% lower. A reduced rate of alternative donor search in South macro-region was observed in all age cohorts. Despite the overall allogeneic transplant rate in Italy is relatively high, there are wide regional differences in access to transplant from alternative donor. Extra-regional migration cannot completely compensate for the lower access to transplant of acute leukaemia patients living in those regions where transplant activity is low.

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Authors and Affiliations

  1. Hemopoietic Transplant Program, Division of Hematology, Azienda Ospedaliera Policlinico Vittorio Emanuele, Catania, Italy

    Giuseppe Milone & Salvatore Leotta

  2. Italian Bone Marrow Donor Registry, E.O. Ospedali Galliera, Genova, Italy

    Nicoletta Sacchi & Anna Gallina

  3. Hemopoietic Transplant Program, Department of Biomedicine e Prevention, University Tor Vergata, Rome, Italy

    Alessandra Picardi

  4. Hemopoietic Transplant Program, Division of Cell Therapy and Transfusion Medicine, Azienda Ospedaliera Careggi, Florence, Italy

    Stefano Guidi

  5. Institute of Physiology CNR, Ospedale Bianchi Melacrino Morelli, Reggio Calabria, Italy

    Giovanni Tripepi

  6. Department of Hematology and Oncology, University of Milan–, Ospedale Papa Giovanni XXIII, Bergamo, Italy

    Alessandro Rambaldi

  7. Hematology, University Hospital Sant’Orsola–, Malpighi, Bologna, Italy

    Francesca Bonifazi

Authors
  1. Giuseppe Milone
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  2. Nicoletta Sacchi
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  3. Anna Gallina
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  4. Salvatore Leotta
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  5. Alessandra Picardi
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  6. Stefano Guidi
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  9. Francesca Bonifazi
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Correspondence to Giuseppe Milone.

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Milone, G., Sacchi, N., Gallina, A. et al. Access to alternative donor hematopoietic search and transplantation for acute leukemia in different macro-regions of Italy. A GITMO/IBMDR study. Bone Marrow Transplant 53, 291–299 (2018). https://doi.org/10.1038/s41409-017-0026-z

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