Fig. 3: Lower T-cell activation by epcoritamab in presence of tumor cells with high expression of the immune regulatory molecule HVEM. | Blood Cancer Journal

Fig. 3: Lower T-cell activation by epcoritamab in presence of tumor cells with high expression of the immune regulatory molecule HVEM.

From: Epcoritamab induces potent anti-tumor activity against malignant B-cells from patients with DLBCL, FL and MCL, irrespective of prior CD20 monoclonal antibody treatment

Fig. 3

A CD69-positive CD4+ and CD8+ allogeneic T-cells after treatment of B-NHL samples with epcoritamab (30 ng/mL) and CD3xCtrl (30 ng/mL) in samples with low or high tumor HVEM expression levels (Mann–Whitney U-test; ***p < 0.001, **p < 0.01). B Epcoritamab-dependent cytotoxicity (30 ng/mL) in B-NHL samples with low and high tumor cell HVEM expression (Mann–Whitney U-test; ns). HVEM expression on healthy donor B-cells was used as cut-off value to stratify between low and high expression. Data are shown as median ±interquartile range. All samples from different B-NHL subtypes and from ND and RR are plotted together.

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