Table 1 Characteristics of study population according to NPM1 mutation status.

From: Nucleophosmin mutations confer an independent favorable prognostic impact in 869 pediatric patients with acute myeloid leukemia

 All patientsNPM1-mutated caseNPM1 wild-type caseP-value
Number (%)86966 (7.6%)803 (92.4%) 
Age, median (year)9.613.49.1<0.001
 <3 years, n (%)211 (24.3%)3 (4.5%)208 (25.9%)<0.001
 3 ≤ Age <10 years, n (%)237 (27.3%)15 (22.7%)222 (27.6%)0.388
 10 ≤ Age <18 years, n (%)421 (48.4%)48 (72.7%)373 (46.5%)<0.001
Sex (% female)47.6%50%47.4%0.690
WBC, × 109/L, Median (rang)31.7 (0.2-610)28.6 (2.1-360.5)32.1 (0.2-610)0.541
FAB classification: N (%)   0.151
M020 (2.8%)0 (0%)20 (3.0%)0.393
M196 (13.5%)15 (26.8%)81 (12.3%)0.002
M2193 (27.1%)13 (23.2%)180 (27.4%)0.499
M32 (0.3%)1 (1.8%)1 (0.2%)0.151
M4192 (26.9%)11 (19.6%)181 (27.5%)0.200
M5160 (22.4%)16 (28.6%)144 (21.9%)0.252
M611 (1.5%)0 (0%)11 (1.7%)>0.999
M739 (5.5%)0 (0%)39 (5.9%)0.064
FLT3/ITD   <0.001
 Positive, n (%)146 (16.8%)24 (36.4%)122 (15.2%) 
 Negative, n (%)722 (83.2%)42(63.6%)680 (84.8%) 
FLT3/ITD allelic ratio
Median (rangE)0.54 (0.03-9.50)0.48 (0.03-9.50)0.55 (0.03-5.19)0.551
Cytogenetic status   <0.001
Normal (n, %)196 (23.7%)51 (81.0%)145 (19.0%) 
Abnormal (n, %)631 (76.3%)12 (19.0%)619 (81.0%) 
SCT in 1st CR   0.001
No (n, %)661 (83.7%)45 (69.2%)616 (85.0%) 
Yes (n, %)129 (16.3%)20 (30.8%)109 (15.0%) 
Protocol   0.915
AAML03P1 (n, %)91 (10.5%)6 (9.1%)85 (10.6%)0.703
AAML0531 (n, %)732 (84.2%)56 (84.8%)676 (84.2%)0.887
CCG-2961 (n, %)46 (5.3%)4 (6.1%)42 (5.2%)0.772
CR status at end of course 1   0.022
CR655 (76.3%)57 (87.7%)598 (75.3%)0.024
Not CR189 (22.0%)8 (12.3%)181 (22.8%)0.050
Death15 (1.7%)0 (0%)15 (1.9%)0.620
CR status at end of course 2   0.014
CR735 (87.2%)63 (96.9%)672 (86.4%)0.015
Not CR88 (10.4%)2 (3.1%)86 (11.1%)0.043
Death20 (2.4%)0 (0%)20 (2.6%)0.392
  1. CR complete remission, FAB French–American–British morphology classification, FLT3/ITD internal tandem duplication of the FLT3 gene, SCT stem cell transplantation, WBC white blood cell count