Fig. 1: Analysis of protein alignment in exon 9 of human and murine CALR. | Blood Cancer Journal

Fig. 1: Analysis of protein alignment in exon 9 of human and murine CALR.

From: Mice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis

Fig. 1

a Alignment analysis in exon 9 of human and murine WT CALR revealed 87.9% identity and 97.0% similarity in the amino acid sequences. b Analysis of the alignment between the common amino acid sequence of human CALR mutants and the counterpart murine CALR mutant. The amino acid sequences of the C-terminal portions of the human CALR del52 mutant and murine CALR del19 mutant are shown. The analysis revealed an identity of only 59.6% but a similarity of 72.3%. Negatively charged amino acids are indicated in blue letters, and positively charged amino acids are indicated in red letters. Alignment analyses were performed using EMBOSS NEEDLE, an online software program (http://emboss.bioinformatics.nl/cgi-bin/emboss/needle)

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