Table 1 Affinity of PD-1 antibody to hPD-1, cynoPD-1, and mPD-1 measured by SPR.
From: CS1003, a novel human and mouse cross-reactive PD-1 monoclonal antibody for cancer therapy
Antigen | Ligand | ka (1/Ms) | kd (1/s) | KD (M) |
|---|---|---|---|---|
hPD-1 | CS1003 | 5.97×105 | 3.66×10−3 | 6.13×10−9 |
cynoPD-1 | CS1003 | 8.09×105 | 7.07×10−3 | 8.74×10−9 |
mPD-1 | CS1003 | 3.23×105 | 1.29×10−3 | 3.99×10−9 |
hPD-1 | Pembrolizumab | 8.79×105 | 2.28×10−3 | 2.59×10−9 |
