Fig. 1: PD-1 antibodies bind to the PD-1 protein and block the PD-1/PD-L1 and PD-1/PD-L2 interactions. | Acta Pharmacologica Sinica

Fig. 1: PD-1 antibodies bind to the PD-1 protein and block the PD-1/PD-L1 and PD-1/PD-L2 interactions.

From: CS1003, a novel human and mouse cross-reactive PD-1 monoclonal antibody for cancer therapy

Fig. 1

a Binding of CS1003 or pembrolizumab to plate-coated recombinant human and mouse PD-1 proteins was assessed by ELISA. b Binding of CS1003 or pembrolizumab to cell surface human PD-1 was determined by FACS. c The functionality of CS1003 or pembrolizumab in blocking human PD-1/PD-L1 interactions was assessed by flow cytometry. d Binding of CS1003 or pembrolizumab to human PD-1, CD28, CTLA-4, ICOS, or BTLA was assessed by ELISA.

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