Table 2 In vitro antiproliferative effects of compound 2, ibrutinib and ACP-196 against TMD8 cells

From: Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton’s tyrosine kinase inhibitors

Compd.Cellular antiproliferative activity (IC50, μM)
20.028 ± 0.014
Ibrutinib0.010 ± 0.005
ACP-1960.014 ± 0.004