Table 1 The chemical structure of compounds 1-8 and in vitro enzymatic inhibitory activities of 1-8, ibrutinib and ACP-196

From: Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton’s tyrosine kinase inhibitors

  1. aData shown are collected from our previous study [23]