Fig. 4 | Acta Pharmacologica Sinica

Fig. 4

From: Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton’s tyrosine kinase inhibitors

Fig. 4

Compound 2 induced cell apoptosis in TMD8 cells. a 2 significantly upregulated the apoptotic level of TMD8 cells equivalent to ibrutinib and ACP-196. b Apoptosis rates were quantitatively depicted. Statistically significant differences were presented as *P < 0.05, **P < 0.01, compared with the control group. c The expression of cleaved PARP and cleaved caspase 3 in TMD8 cells was determined by Western blot analysis

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