Fig. 2 | Acta Pharmacologica Sinica

Fig. 2

From: Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton’s tyrosine kinase inhibitors

Fig. 2

The effects of compound 2, ibrutinib, and ACP-196 on the phosphorylation of BTK at Tyr223 in TMD8 cells. Cells were treated with indicated concentrations of 2, ibrutinib, and ACP-196 for 4 h and the total cell lysates were analyzed by Western blot analysis

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