In our previous article entitled “Low-intensity walking as mild medication for pressure control in prehypertensive and hypertensive subjects: how far shall we wander?” published in this journal , we reported mild but significant reductions in both blood pressure (BP) and heart rate (HR) after low-intensity walking at a speed of 3 km/h (2.5 metabolic equivalents of task, METs), accompanied by a transient elevation in urine β-endorphin. In a recent study observing environmental influence on low-intensity walking, we found unexpectedly interesting results that we would like to share with the readers of the journal.
In the aforementioned study, walking was usually performed in the open air during the day but occasionally indoors when it was raining or either too cold or too hot outside. We further designed a study of the difference between low-intensity walking with sunshine (sunny walking) and without sunshine (sunless walking) for 1 h in normotensive subjects aged 19–74 years. Sunny walking was performed on sunny days in open venues where the participants walked in the sun (sunbathed). Sunless walking was performed indoors with only indoor lamplight or outdoors with minimal sunlight on overcast days.
It was interesting to find that sunny walking and sunless walking resulted in similar reductions in resting HR but discrete effects on BP. As shown in Table 1, sunny walking caused a brief but significant decrease in both resting BP and HR, as we observed previously [1, 2]. Sunless walking, however, produced no clinically meaningful reduction in BP in addition to the reduced HR. Sunny walking also resulted in elevated urine β-endorphin output during walking, whereas sunless walking did not. The lack of β-endorphin change during sunless walking was contrary to our previous proposal that low-intensity walking per se elevated β-endorphin, which might partly count for the walking-related reduction in BP. β-Endorphin was tested with a previously used enzyme-linked immunosorbent assay (Wuhan Elabscience Biotechnology Co., Ltd, China) [1, 2]. These findings suggest that low-intensity walking reduced HR independently of β-endorphin. Different mechanisms should be involved in the cardiovascular effects of walking in different environments. Additionally, sunny walking has a greater effect.
Sunny walking elevated the surface temperature of the extremities (palm) but not that of the forehead (Table 1). Sunless walking, in contrast, decreased the temperature of both the palm and forehead. The warming of the extremities by the sun during walking could promote circulation and vasodilation of the skin vasculature that may contribute to BP reduction in addition to β-endorphin. The surface temperature reduction during walking with no sunlight exposure might be caused by walking-enhanced circulation that promoted the dissipation of body heat without much heat-related cutaneous vasodilation.
Sunlight includes a broad spectrum of wavelengths, including ultraviolet (UV), far-infrared and infrared rays, which have been shown to affect cardiovascular function in different studies [3,4,5]. It was reported that whole body UV radiation was associated with the cutaneous release of enzyme-independent nitric oxide (NO) and a greater decrease in BP than was produced by skin heating [3, 4]. During our sunny walking, a limited area of body skin (i.e., the head and hands) was exposed to sunlight. It remains to be determined which contributes more to lowering BP during sunny walking, UV radiation-related NO, far-infrared/infrared radiation, the heating of the body, or other vasodilating factors.
Collectively, our data suggest that sunny walking lowers BP and HR by multiple mechanisms. Mild exercise in the open air with sunlight exposure may provide additional benefits to the cardiovascular system in hypertensive individuals who perform little outdoor physical activity.
Lu Q, Wang S, Liu YX, Chen H, Zhang R, Zhang WH, et al. Low-intensity walking as mild medication for pressure control in prehypertensive and hypertensive subjects: how far shall we wander? Acta Pharmacol Sin. 2019; 40: in press. https://doi.org/10.1038/s41401-018-0202-8.
Wang SM, Chen YC, Lu Q, Wang J, Zhong MF, Chen H, et al. Low-speed walking for three kilometers was effective to lower short-term blood pressure and heart rate with increased β-endorphin release in normotensive and hypertensive subjects. Chin J Hypertens. 2018;26:953–61.
Oplander C, Volkmar CM, Paunel-Gorgulu A, van Faassen EE, Heiss C, Kelm M, et al. Whole body UVA irradiation lowers systemic blood pressure by release of nitric oxide from intracutaneous photolabile nitric oxide derivates. Circ Res. 2009;105:1031–40.
Liu D, Fernandez BO, Hamilton A, Lang NN, Gallagher JM, Newby DE, et al. UVA irradiation of human skin vasodilates arterial vasculature and lowers blood pressure independently of nitric oxide synthase. J Invest Dermatol. 2014;134:1839–46.
Aragane Y, Higashino H. The “Enseki” sandbath: A novel, safe and effective far-infrared bathing procedure for health. Photodermatol Photoimmunol Photomed. 2019;35:31–9.
This work was supported by grants from the National Natural Science Foundation of China to Hong Chen (No. 30971154, 31171099) and Wen-hui Zhang (No. 81373468). We are grateful to Dr. Hai Su, Wei-li Shen and Yoshinori Aragane for engaging in active discussions.
The authors declare no competing interests.
About this article
Cite this article
Zhang, R., Chen, H., Liu, Yx. et al. Sunny walking counts more. Acta Pharmacol Sin 40, 1256–1257 (2019). https://doi.org/10.1038/s41401-019-0241-9