Fig. 2: Changes in neurotransmitter levels after bumetanide administration. | Translational Psychiatry

Fig. 2: Changes in neurotransmitter levels after bumetanide administration.

From: Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios

Fig. 2

a Group comparisons of insular GABA concentration before and after treatment. Dots represent insular GABA concentration of each subject. b Trajectories of the change of insular GABA concentration before and after treatment. Dots represent GABA concentration of each subject from bumetanide group, and triangles represent the concentration of control. c, e Group comparisons of insular GABA/Glx ratios (c) visual GABA/Glx ratios (e) before and after treatment. d, f Trajectories of the change of both the insular GABA/Glx ratios (d) and the visual GABA/Glx ratios (f). Dots represent GABA/Glx ratios of each subject from bumetanide group, and triangles represent the concentration of control. Abbreviations: INS-insular cortex, VC-visual cortex, GABA -γ-aminobutyric acid, Glx – glutamate and glutamine.

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