Fig. 1: NF-κB activation pathway in bipolar disorder. | Translational Psychiatry

Fig. 1: NF-κB activation pathway in bipolar disorder.

From: Involvement of the nuclear factor-κB transcriptional complex in prefrontal cortex immune activation in bipolar disorder

Fig. 1

The NF-κB transcriptional complex is composed of heterodimers between NF-κB family members, including NF-κB1, NF-κB2, and other members of the NF-κB family that contain Rel homology domains including RelA, RelB, and cRel. Receptor activation (IL-1R, TNFR) increases transcriptional activity (green arrow) of the NF-κB transcriptional complex, leading to higher mRNA levels for NF-κB-regulated immune markers, such as IFITMs. In contrast, the NF-κB site-binding protein HIVEP2 inhibits NF-κB transcriptional activity (red line). Transcript levels in bipolar disorder subjects relative to unaffected comparison subjects are indicated by the direction of the open arrows.

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