Table 2 Candidate gene expression data.

From: Whole-blood expression of inflammasome- and glucocorticoid-related mRNAs correctly separates treatment-resistant depressed patients from drug-free and responsive patients in the BIODEP study

Genes Mean expression levels [95% confidence interval] Group test
Healthy controls (Con) N = 40 Treatment-responders (Resp) N = 36 Drug-free (Free) N = 36 Treatment-resistant (TRD) N = 58 Statistic P value Post hoc
A2M 1.02 [0.95–1.09] 1.28 [1.22–1.34] 1.24 [1.17–1.31] 1.23 [1.19–1.27] F = 14.11 <0.001 TRD > Con Free > Con Resp > Con
CRP 1.03 [0.96–1.09] 1.13 [1.07–1.18] 1.18 [1.08–1.29] 1.18 [1.13–1.22] F = 4.54 0.004 TRD > Con Free > Con
IL-1beta 1.07 [1.04–1.10] 1.16 [1.03–1.28] 1.22 [1.18–1.26] 1.32 [1.27–1.37] F = 12.24 <0.001 TRD > Con TRD > Resp Free > Con
IL-6 1.06 [1.03–1.08] 1.32 [1.26–1.38] 1.28 [1.24–1.32] 1.23 [1.17–1.28] F = 19.675 <0.001 TRD > Con Free > Con Resp > TRD Resp > Con
MIF 1.00 [0.96–1.05] 1.13 [1.07–1.20] 1.30 [1.24–1.37] 1.27 [1.23–1.30] F = 29.62 <0.001 TRD > Con TRD > Resp Free > Con Free > Resp Resp > Con
TNF-alpha 1.06 [1.00–1.11] 1.24 [1.21–1.27] 1.30 [1.27–1.33] 1.32 [1.28–1.35] F = 35.09 <0.001 TRD > Con TRD > Resp Free>Con Resp>Con
P2RX7 1.03 [0.95–1.12] 0.79 [0.74–0.84] 1.27 [1.13–1.40] 1.25 [1.20–1.30] F = 29.69 <0.001 TRD > Con TRD > Resp Free > Con Free > Resp Con > Resp
CCL2 1.03 [0.99–1.06] 0.99 [0.94–1.05] 1.25 [1.20–1.29] 1.14 [1.11–1.17] F = 27.485 <0.001 TRD > Con TRD > Resp Free > Con Free > Resp Free > TRD
CXCL12 1.06 [0.98–1.14] 0.93 [0.86–1.00] 1.03 [0.96–1.10] 1.08 [1.04–1.12] F = 4.49 0.005 TRD > Resp Con > Resp
AQP4 1.03 [0.97–1.09] 1.03 [0.96–1.11] 1.03 [0.97–1.09] 1.08 [1.01–1.16] F = 0.62 0.605  
ISG15 0.99 [0.91–1.06] 1.03 [0.95–1.12] 0.96 [0.88–1.04] 1.03 [0.95–1.10] F = 0.64 0.59  
STAT1 1.06 [1.00–1.11] 1.08 [1.03–1.14] 1.23 [1.16–1.30] 1.19 [1.15–1.23] F = 9.67 <0.001 TRD > Con TRD > Resp Free > Con Free > Resp
USP18 0.99 [0.91–1.07] 1.02 [0.93–1.10] 1.01 [0.95–1.08] 1.03 [0.98–1.09] F = 0.245 0.865  
FKBP5 1.04 [0.97–1.10] 1.13 [1.08–1.18] 1.27 [1.23–1.30] 1.27 [1.25–1.29] F = 30.31 <0.001 TRD > Con TRD > Resp Free > Con Free > Resp Resp > Con
GR 1.05 [1.02–1.08] 1.01 [0.97–1.05] 0.83 [0.80–0.87] 0.87 [0.84–0.90] F = 40.28 <0.001 TRD < Con TRD < Resp Free < Con Free < Resp
SGK1 1.06 [1.03–1.09] 1.05 [1.02–1.08] 1.23 [1.20–1.26] 1.05 [1.02–1.08] F = 32.34 <0.001 Free > Con Free > Resp Free > TRD
  1. #Post hoc: ‘one group > /< one group’ means that the first category group has score statistically larger/smaller than the second group.