Table 1 Demographic, clinical and immune data.

From: Whole-blood expression of inflammasome- and glucocorticoid-related mRNAs correctly separates treatment-resistant depressed patients from drug-free and responsive patients in the BIODEP study

  Mean [95% confidence interval]/N (%) in category Group test
Healthy controls (Con) N = 40 Treatment-responders (Resp) N = 36 Drug-free (Free) N = 36 Treatment-resistant (TRD) N = 58 Statistic P value Post hoc #
Age, years [95% CI] 35.1 (32.7–37.5) 36.0 (33.2–38.7) 34.3 (31.8–36.9) 35.9 (34.0–37.8) F = 0.43 0.73  
Gender, female, N [%] 26 (65.0%) 24 (66.7%) 23 (63.9%) 41 (70.7%) Chi2 = 0.59 0.90  
Education level [below university yes/no %] 9/31 (22.5%/77.5%) 9/27 (25.0%/75.0%) 15/21 (41.7%/58.3%) 22/36 (37.9%/62.1%) Chi2 = 14.6 0.26  
Relationship status [divorced, separated or single yes/no] 8/32 (20.0/80.0%) 13/23 (36.1/63.9%) 18/18 (50.0/50.0%) 30/28 (51.7/48.3%) Chi2 = 21.6 0.01  
HAM-D total score [95% CI] 0.7 (0.3–1.0) 3.1 (2.5–3.8) 19.9 (19.0–20.9) 18.1 (17.3–18.9) F = 683.6 <0.001 Each vs others
State anxiety [95% CI] 26.7 (24.7–28.7) 36.8 (33.2–40.4) 52.8 (49.0–56.6) 49.5 (46.1–52.8) F = 51.19 <0.001 Con < others Resp vs. others
Trait anxiety [95% CI] 27.8 (26.2–29.5) 44.1 (40.4–47.8) 60.2 (56.8–63.9) 61.0 (58.2–63.9) F = 114.5 <0.001 Con < others Resp vs. others
Number of failed antidepressants (lifetime) [95% CI] 0.0 0.83 (0.47–1.20) 0.89 (0.45–1.33) 1.74 (1.30–2.18) F = 15.7 <0.001 Con < others TRD > others
Duration of exposure to antidepressants (lifetime) [95% CI] 0.0 20.7 (15.8–25.6) 18.9 (12.2–25.6) 24.6 (20.5–28.8) F(2,101) = 1.31 (three groups) 0.27  
Total Score CTQ 40.1 (38.2–42.1) 47.6 (45.4–49.9) 54.1 (51.7–56.6) 53.4 (51.6–55.3) Wald Chi2 = 106.6 <0.001 Con < others Resp vs. other
Smoking % current/past/never 12.8/25.6 /61.6 14.7/17.6 /67.7 11.4/20.0 /68.6 21.1/21.1 /57.8 Chi2 = 2.8 0.83  
Alcohol use % current/past/never 59.0/0.0 /41.0 54.3/14.3 /31.4 55.5/13.9 /30.6 63.8/3.4 /32.8 Chi2 = 9.9 0.13  
BMI, kg/m2 25.4 (23.8–27.0) 27.6 (25.6–29.7) 26.0 (24.6–27.3) 28.5 (26.3–30.7) F = 2.35 0.073  
CRP, mg/L 1.1 (0.8–1.6) 2.2 (1.5–3.2) 2.9 (2.0–4.2) 5.0 (3.7–6.7) Wald Chi2 = 40.49 <0.001 TRD > Con TRD > Resp Free > Cont
Total white cells 5.9 (5.5–6.4) 6.2 (5.5–6.9) 6.6 (6.1–7.2) 7.2 (6.6–7.7) F = 4.09 0.008 TRD > Con
Lymphocytes absolute 1.9 (1.7–2.0) 1.9 (1.7–2.1) 1.9 (1.8–2.1) 2.1 (2.0–2.3) F = 2.65 0.051  
Monocytes absolute 0.4 (0.35–0.44) 0.43 (0.37–0.49) 0.42 (0.38–0.47) 0.40 (0.37–0.44) F = 0.46 0.710  
Neutrophils absolute 3.51 (3.14–3.89) 3.64 (3.15–4.41) 4.09 (3.60–4.57) 4.36 (3.92–4.80) F = 3.30 0.022 TRD > Con
Basophils absolute 0.02 (0.02–0.03) 0.03 (0.02–0.03) 0.03 (0.02–0.03) 0.03 (0.02–0.03) Wald Chi2 = 9.82 0.611  
Eosinophils absolute 0.15 (0.12–0.19) 0.19 (0.14–0.24) 0.18 (0.14–0.24) 0.23 (0.18–0.28) Wald Chi2 = 6.22 0.101  
  1. #Post hoc: ‘specific group category vs. others’ means that the specific group has mean score statistically different (larger or smaller) than the scores of others group categories;
  2. ‘one group > /< one group’ means that the first category group has score statistically larger/smaller than the second group.