Fig. 3: Psychophysiological and neural responses during reinstatement test. | Translational Psychiatry

Fig. 3: Psychophysiological and neural responses during reinstatement test.

From: Opposing roles for amygdala and vmPFC in the return of appetitive conditioned responses in humans

Fig. 3

a Return of appetitive conditioned responses was observed during fMRI reinstatement test with significant larger SCRs towards the CS+ compared to the CS− during the first 5 CS+ and CS− presentations in both phases (t(32) = 2.25, p = .031). Error bars represent within-subject SEM81,82. b Elevated BOLD response in the contrast CS+ > CS− in the left amygdala over phases (MNI peak at [x: −26, y: 2, z: −26], pFWE ROI = .01). c Interaction of differential BOLD responses with test phase in the right NAcc due to CS+ related activation declines from early to late reinstatement test (MNI peak at [x: 16, y: 8, z: −10], pFWE ROI = 016). All t-maps are displayed on a visualization threshold of p < .005 uc with k ≥ 20 cluster extend

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