Table 2 Top gene set enrichment for WGCNA modules

From: Dopamine perturbation of gene co-expression networks reveals differential response in schizophrenia for translational machinery

Module Top KEGG pathway FDR Top GO-terma FDR
  Baseline
Black hsa05162: Measles 2.0 × 10−8 0051607: Defense response to virus 5.2 × 10−17
Blue hsa04141: Protein processing in ER 5.4 × 10−66 0006888: ER to Golgi vesicle transport 5.3 × 10−30
Brown hsa03010: Ribosomeb 2.3 × 10−110 0006614: SRP protein targeting to ERc 4.0 × 10−141
Green hsa04668: TNF signaling 9.6 × 10−12 0006954: Inflammatory response 9.7 × 10−9
Green-Yellow hsa04110: Cell cycle 1.2 × 10−20 0051301: Cell division 1.2 × 10−32
Magenta hsa03008: Ribosome biogenesis 4.3 × 10−12 0044822: Poly(A) RNA binding 1.5 × 10−72
Purple hsa04960: Sodium reabsorption 0.63 0005201: Extracellular matrix structure 0.18
  DA-stimulated
Black hsa04961: Endocrinal calcium reabsorption 0.014 0007165: Signal transduction 0.011
Blue hsa04141: Protein processing in ER 3.1 × 10−48 0036498: IRE1-mediated protein response 4.4 × 10−21
Brown hsa03010: Ribosome 1.1 × 10−125 0006614: SRP protein targeting to ER 2.7 × 10−161
Green hsa04064: NF-kappa B signaling 4.1 × 10−8 0006954: Inflammatory response 6.4 × 10−6
Green-Yellow hsa04110: Cell cycle 1.3 × 10−14 0051301: Cell division 1.2 × 10−44
Magenta hsa04612: Antigen processing 0.037 0044822: Poly(A) RNA binding 2.6 × 10−24
  1. aTested GO-terms related to biological processes and molecular functions in DAVID v. 6.8
  2. bGenes from the brown baseline module belonging to this pathway (n = 80): MRPL33, MRPL34, MRPS21, RPL10, RPL10A, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL15, RPL17, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL22L1, RPL23, RPL23A, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36, RPL36A, RPL37, RPL37A, RPL38, RPL39, RPL4, RPL41, RPL5, RPL6, RPL7, RPL7A, RPL8, RPL9, RPLP0, RPLP1, RPLP2, RPS10, RPS11, RPS12, RPS13, RPS14, RPS15, RPS15A, RPS16, RPS18, RPS19, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS27, RPS27A, RPS28, RPS29, RPS3, RPS3A, RPS4X, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, and UBA52
  3. cGenes from the brown baseline module belonging to this GO-term (n = 77): RPL10, RPL10A, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL15, RPL17, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL23, RPL23A, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36, RPL36A, RPL37, RPL37A, RPL38, RPL39, RPL4, RPL41, RPL5, RPL6, RPL7, RPL7A, RPL8, RPL9, RPLP0, RPLP1, RPLP2, RPS10, RPS11, RPS12, RPS13, RPS14, RPS15, RPS15A, RPS16, RPS18, RPS19, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS27, RPS27A, RPS28, RPS29, RPS3, RPS3A, RPS4X, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, SRP14, and UBA52