Fig. 3: Box-and-whisker plots showing the 4 treatment groups divided into responders (green) and non-responders (blue) | Translational Psychiatry

Fig. 3: Box-and-whisker plots showing the 4 treatment groups divided into responders (green) and non-responders (blue)

From: Treatment of bipolar depression with minocycline and/or aspirin: an adaptive, 2×2 double-blind, randomized, placebo-controlled, phase IIA clinical trial

Fig. 3

The box shows inter quartile range (IQR, i.e., 25–75%) around the median (line in a box) and the whisker shows data range (minimum to maximum values) except for outliers (diamonds). The natural logarithm of the serum IL-6 protein concentration is shown on the y-axis. There was a significant 3-way interaction between aspirin, minocycline, and IL-6 (χ21 = 7.08, p(2t) = 0.008) on response rates. Follow-up analysis showed that participants in the M + P group with higher baseline IL-6 levels were more likely to be classified as treatment responders than participants in the M + P group with lower IL-6 levels (χ21 = 7.72, p(2t) = 0.005). **p < 0.01 (two-tailed test);  = outlier, defined as a data point outside of 75% + 1.5*IQR or 25%–1.5*IQR

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