Fig. 2: Percentage of responders (y-axis) in each of the 4 treatment groups shown individually (top panel) and the two aspirin groups (M + A and A + P) vs. the two non-aspirin groups (M + P and P + P) (bottom panel) | Translational Psychiatry

Fig. 2: Percentage of responders (y-axis) in each of the 4 treatment groups shown individually (top panel) and the two aspirin groups (M + A and A + P) vs. the two non-aspirin groups (M + P and P + P) (bottom panel)

From: Treatment of bipolar depression with minocycline and/or aspirin: an adaptive, 2×2 double-blind, randomized, placebo-controlled, phase IIA clinical trial

Fig. 2

Top panel: participants receiving minocycline plus aspirin showed a better response rate compared with participants receiving double placebo (χ12 = 3.35, p(1t) = 0.034, odds ratio (OR) = 2.93, NNT = 4.7). Bottom panel: there was a significant main effect of aspirin on the clinical response rate (χ12 = 5.52, p(2t) = 0.019, OR = 3.67) but no significant effect of minocycline (χ12 = 0.01, p = 0.911) or interaction between aspirin and minocycline (χ12 = 0.19, p = 0.659). The NNT to obtain a response to aspirin (M + A and A + P vs. M + P and P + P) was 4.2. The NNT for the M + A and A + P vs. the P + P comparison was 4.0. #p < 0.05 (one-tailed test); *p < 0.05 (two-tailed test)

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