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STRIPE partners in precision medicine series: provider perspective

The Pharmacogenomics Journal volume 24, Article number: 28 (2024) Cite this article

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During the “Provider Perspective” session, Dr. Paldeep Atwal, Kathryn Meintsma, Dr. Martin Dawes, and Dr. Gary Marchant provided their perspectives for health care providers who are considering the incorporation of science and technology into their clinical setting during a discussion moderated by Dr. Christine Formea. Speakers discussed areas of ongoing debate including genomics malpractice, clinical use, clinical decision support, and compliance.

Dr. Paldeep Atwal MD, MBA, Physician and Director of Atwal Clinic for Genomic and Personalized Medicine and Medical Director for Genetic Services at Everly Health Solutions, shared a concierge clinic perspective. He discussed direct-to-consumer testing versus consumer-initiated testing approaches for pharmacogenomics. Direct-to-consumer testing does not require the involvement of a health care provider while consumer-initiated testing requires an order from a health care provider and is handled by the clinical care team. Consumer-initiated testing can be more beneficial for clinical decision making due to clinical oversight and CLIA-certified clinical laboratory testing. Pharmacogenomics barriers exist due to lack of awareness of its benefits. When patients initiate their own pharmacogenomics testing, barriers can be reduced to increase access. Additionally, Dr. Atwal recommended that health care providers seek the specialized expertise of pharmacogenomics-trained pharmacists as they begin incorporating these skills into their clinical practice. As non-genetics trained health care providers begin using this information, it is important to remember to use pharmacogenomics in conjunction with other medication information including drug-drug interactions and phenoconversion (i.e., a mismatch between a person’s genotype-predicted drug metabolism and their actual or observed phenotypic drug metabolism due to non-genetic factors such as drug inducers or inhibitors) to create actionable medical plans that can be shared with patients and other health care providers for more effective clinical care. He encouraged using genomics resources such as the Clinical Pharmacogenetics Implementation Consortium (CPIC) website for additional information.

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Fig. 1: Four tips for primary care providers to begin using pharmacogenomics.

References

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Acknowledgements

The Partners in Precision Medicine series was developed by the Standardizing Laboratory Practices in Pharmacogenomics (STRIPE) Initiative Education Team. STRIPE is a Collaborative Community, serving as a continuing forum in which private- and public-sector members, including the FDA, work together on medical device challenges to achieve common objectives and outcomes. More information about the STRIPE initiative can be found by visiting https://www.stopadr.org/stripe. To view the complete “Partners in Precision Medicine” webinar series, visit https://tvworldwide.com/events/pipm/210929/default.cfm.

Author information

Authors and Affiliations

  1. Department of Pharmacy and Precision Medicine Institute, Children’s Hospital Colorado, Aurora, CO, USA

    Christine M. Formea

  2. Atwal Clinic, Palm Beach, FL, USA

    Paldeep Atwal

  3. Everly Health Solutions, Austin, TX, USA

    Paldeep Atwal

  4. HealthRoad Legal, PLLC, Watertown, MN, USA

    Kathryn Meintsma

  5. Department of Family Practice, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada

    Martin Dawes

  6. Center for Law, Science & Innovation, Sandra Day O’Connor College of Law, Arizona State University, Phoenix, AZ, USA

    Gary Marchant

  7. Oregon Health & Science University, Knight Cancer Institute, Portland, OR, USA

    Ben L. Kong

  8. Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center Jerry H. Hodge School of Pharmacy, Dallas, TX, USA

    J. Shawn Jones

  9. Department of Pharmacy Practice, Irma Lerma Rangel School of Pharmacy, Texas A&M University, Kingsville, TX, USA

    Sara L. Rogers

  10. Department of Translational Medical Sciences, School of Medicine, Texas A&M University, Bryan, TX, USA

    Sara L. Rogers

  11. Center for Genomic and Precision Medicine, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA

    Sara L. Rogers

  12. American Society of Pharmacovigilance, Houston, TX, USA

    Sara L. Rogers

Authors
  1. Christine M. Formea
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  2. Paldeep Atwal
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  3. Kathryn Meintsma
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  4. Martin Dawes
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  5. Gary Marchant
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  6. Ben L. Kong
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  7. J. Shawn Jones
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  8. Sara L. Rogers
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Contributions

SR, JSJ, BK, and CMF were responsible for designing the webinar series concept. PA, KM, MD, GM, BK, SR, and CMF were responsible for developing content for this provider perspective webinar. SR and CMF were responsible for extracting data from recordings. CMF, KM, MD, GM, BK, SR, and JSJ contributed to writing the report.

Corresponding author

Correspondence to Christine M. Formea.

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Competing interests

1. CF: No competing financial interests. 2. PA: Founder of Atwal Clinic. 3. PA: Medical Director for Everly Health Solutions. 4. KM: No competing financial interests. 5. MD: CEO of GenXys Health Care Systems. 6. GM: No competing financial interests. 7. SR: No competing financial interests. 8. JSJ: No competing financial interests. 9. BK: consultant for Clarified Precision Medicine.

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Formea, C.M., Atwal, P., Meintsma, K. et al. STRIPE partners in precision medicine series: provider perspective. Pharmacogenomics J 24, 28 (2024). https://doi.org/10.1038/s41397-024-00348-9

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  • DOI: https://doi.org/10.1038/s41397-024-00348-9

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