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Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria

The Pharmacogenomics Journal volume 20, pages 87–93 (2020)Cite this article

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Abstract

H1 nonsedating antihistamines, such as desloratadine, are first-line treatment options for chronic spontaneous urticaria (CSU). However, desloratadine induces various degrees of sedation side effect in CSU patients, and no biomarkers currently exist for predicting the severity of such side effect. Herein, we evaluated the association between HRH1 gene rs901865 polymorphism and the severity of sedation side effect following desloratadine therapy in patients with CSU. We found that 20 of the 114 patients (17.50%) showed sedation side effect after desloratadine treatment, and 3 patients (2.63%) experienced serious sleepiness. The frequency of HRH1 rs901865 G allele was significantly higher in patients who experienced sedation than in patients with rs901865 A allele (p = 0.0009). Moreover, patients with the rs901865 G/G genotype suffered a more serious sedation side effect than patients with the rs901865 G/A genotype (p = 0.005). These results provide evidence that the HRH1 rs901865 G/G polymorphism is associated with severe sedation side effect after desloratadine treatment. Thus, the HRH1 rs901865 allele may potentially be used as a biomarker for predicting the severity of sedation side effect in patients suffering from CSU and treated with desloratadine.

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (grant Nos. 81430075 and 81225013 to Chen X.; grant No. 81673065 to Jie Li), Science and Technology Project of Hunan Province (2014SK3108 to Jie Li), Science and Technology Committee of Haidian District (C4WNX-001 to Juan Li).

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China

    Juan Li, Wangqing Chen, Zhaoqian Liu, Wei Zhang & Xiang Chen

  2. Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China

    Juan Li, Wangqing Chen, Cong Peng, Wu Zhu, Juan Su, Jie Li & Xiang Chen

  3. Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China

    Juan Li, Cong Peng, Wu Zhu, Juan Su, Jie Li & Xiang Chen

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  1. Juan Li
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Li, J., Chen, W., Peng, C. et al. Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria. Pharmacogenomics J 20, 87–93 (2020). https://doi.org/10.1038/s41397-019-0094-0

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