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Motor functional recovery efficacy of scaffolds with bone marrow stem cells in rat spinal cord injury: a Bayesian network meta-analysis


Study design

A Bayesian network meta-analysis.


Spinal cord injury (SCI) can profoundly influence human health and has been linked to lifelong disability. More high-level evidence-based medical research is expected to evaluate the value of stem cells and biomaterial scaffold material therapy for SCI.


We performed a comprehensive search of Web of Science, Cochrane databases, Embase, and PubMed databases. 18 randomized controlled trials including both scaffolds and BMSCs were included. We performed a Bayesian network meta-analysis to compare the motor functional recovery efficacy of different scaffolds with BMSCs in rat SCI.


In our Bayesian network meta-analysis, the motor functional recovery was found to benefit from scaffolds, BMSCs, and BMSCs combined with scaffolds, but the scaffold and BMSC groups had similar motor functional recovery efficacy, and the BMSCs combined with scaffolds group appeared to show better efficacy than BMSCs and scaffolds alone. Subgroup analysis showed that BMSCs+fibrin, BMSCs+ASC, BMSCs+gelatine, and BMSCs+collagen were the best four treatments for SCI in rat models.


These Bayesian network meta-analysis findings strongly indicated that BMSCs combined with scaffolds is more effective to improve motor functional recovery than BMSCs and scaffolds alone. The fibrin, gelatine, ASC, and collagen may be favourable scaffolds for the injured spinal cord and that scaffolds with BMSCs could be a promising option in regeneration therapy for patients with SCI.

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Fig. 1
Fig. 2: Network meta-analysis of the motor functional recovery for scaffolds, BMSCs, and BMSCs combined with scaffolds.
Fig. 3: Subgroup analysis of different scaffolds with BMSCs.


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This work was supported by the Natural Science Foundation of China (81702667) and Shandong Medical and Health Science and Technology Development Project (2016WS0460).

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WL conceived the study and wrote the manuscript, DZ analyzed the data. WL and YS extracted the data. All authors reviewed the manuscript.

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Correspondence to Wei Liu.

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The authors declare no competing interests.

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Zhang, D., Sun, Y. & Liu, W. Motor functional recovery efficacy of scaffolds with bone marrow stem cells in rat spinal cord injury: a Bayesian network meta-analysis. Spinal Cord (2022).

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