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Association between age and incidence of deep vein thrombosis in patients with spinal cord injury: an observational cross-sectional study


Study design

Cross-sectional study.


To elucidate the association between age and incidence of deep vein thrombosis (DVT) in patients with spinal cord injury (SCI).


Rehabilitation Medicine Department of the First Affiliated Hospital of China University of Science and Technology.


Patients from August 2018 to December 2020 with SCI (N = 260) were tertiles divided the age into three groups to analyze the association between age and incidence of DVT.


American Spinal Cord Injury Association impairment scale (AIS), urinary tract infection (UTI), pulmonary infection (PI), and anticoagulation therapy (AT) were confounders for the association between age and incidence of DVT. The incidence of DVT increased by 1.07-fold (Non-adjusted model, OR = 1.07, P < 0.001), 1.05-fold (Minimally-adjusted model: adjusted for confounders, OR = 1.05, P = 0.010) and 1.06-fold [Fully-adjusted model: adjusted for confounders and unbalanced probable variables: AIS, UTI, PI, AT, Sex, D-dimer(new), Fibrinogen (new), Modes of injury and Level of injury, OR = 1.06, P = 0.012] when age increased by 1 year. The incidence of DVT had an increasing trend with age in different age tertile in the three models (P for trend <0.05). Age had a linearly association with incidence of DVT (OR = 1.07, P = 0.065) and stable in different subgroups, for lower age, the association was also linearly (OR = 4.40, P = 1.000), for middle (fold point = 46.46, P < 0.001) and higher age (fold point = 66, P = 0.017), the association was curvilinear.


Age had a linearly association with incidence of DVT. Quitting smoking, preventing/treating UTI and AT should be adopted in advance for patients with SCI for all age, especially for older.

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Fig. 1: Flowchart of the study.
Fig. 2: Graph depicting the association between age and incidence of DVT.
Fig. 3: Forest plot of the subgroup analysis between age and incidence of DVT.

Data availability

The datasets analyzed during the current study are available from the corresponding author on reasonable request.


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We would like to thank Tingting Zhang, CuicuiChang, Tingting Bao, Nanzu Chengjiang, Liai Sun, and Lina Ma for collecting the data. We would also like to thank Xinglin Chen for helping us analyze the data and thanks to Editage ( for editing the English.

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Authors and Affiliations



JLZ: Conducted the study and wrote the draft. YYF: Designed the study, interpreted the data, and edited the manuscript. HYP, YT, JZ, and SSZ: Collected the data. CW: Planned the project, created, and statistical analyzed the data. The authors all read and approved the final paper.

Corresponding author

Correspondence to Cheng Wang.

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The authors declare no competing interests.

Ethics approval and consent to participate

Informed consent was waived due to the nature of the retrospective study, which consistent with ethical requirements and waiver from the Ethics Committee of First Affiliated Hospital of the University of Science and Technology of China (Anhui Provincial Hospital), this study also approved by the committee, the approved number was 2020-RE-008.

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Zhang, J., Fang, Y., Pang, H. et al. Association between age and incidence of deep vein thrombosis in patients with spinal cord injury: an observational cross-sectional study. Spinal Cord (2022).

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