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SCI & Exercise

# Development and deployment of an at-home strength and conditioning program to support a phase I trial in persons with chronic spinal cord injury

## Abstract

### Study design

Nonrandomized clinical trial (NCT02354625).

### Objectives

As a part of a Phase I clinical trial to assess the safety of autologous human Schwann cells (ahSC) in persons with chronic spinal cord injury (SCI), participants engaged in a multimodal conditioning program pre- and post-ahSC transplantation. The program included a home-based strength and endurance training program to prevent lack of fitness and posttransplantation detraining from confounding potential ahSC therapeutic effects. This paper describes development, deployment, outcomes, and challenges of the home-based training program.

### Setting

University-based laboratory.

### Methods

Development phase: two men with paraplegia completed an 8-week laboratory-based ‘test’ of the home-based program. Deployment phase: the first four (two males, two females) participant cohort of the ahSC trial completed the program at home for 12 weeks pre and 20 weeks post ahSC transplant.

### Results

Development phase: both participants improved their peak aerobic capacity (VO2peak) (≥17%), peak power output (POpeak) (≥8%), and time to exhaustion (TTE) (≥7%). Deployment phase: pretransplant training minimally increased fitness in the two male participants (≥6% POpeak and ≥9% TTE). The two women had no POpeak changes and slight TTE changes (+2.6 and −1.2%, respectively.) All four participants detrained during the posttransplant recovery period. After posttransplant retraining, all four participants increased TTE (4–24%), three increased VO2peak (≥11%), and two increased POpeak (≥7%).

### Conclusions

Home-based strength and condition programs can be effective and successfully included in therapeutic SCI trials. However, development of these programs requires substantial content knowledge and experience.

## Introduction

The Miami Project to Cure Paralysis conducted a Phase I clinical trial (NCT02354625) to assess the safety of autologous human Schwann cells (ahSC) as a therapeutic agent for functional recovery among persons with chronic spinal cord injury (SCI). As a part of this trial, participants completed a multimodal whole-body conditioning program pre- and post-ahSC transplantation. This included locomotor training and functional electrical stimulation (FES) performed in the laboratory and strength and endurance training performed at home. The goals of the strength and endurance program were to (1) condition individuals prior to undergoing surgery and (2) prevent a lack of fitness and/or posttransplantation detraining from confounding potential therapeutic effects of ahSC transplantation. The strength and endurance program was specifically developed for home-based use by the participants.

The impetus for implementing a home-based program was our experience in a feasibility study of the multimodal program [1]. That study included body-weight-supported treadmill training for locomotion (3× weekly), FES for activation of sublesional muscles (3× weekly), and upper body circuit resistance training (CRT) for strength and endurance conditioning (2× weekly) [1]. Participants were required to come to the research facility 5 days a week for 19 weeks, which negatively affected compliance. Therefore, for the phase I ahSC trial, to reduce participant burden, mitigate barriers, and increase compliance, we developed a home-based strength and conditioning program [2].

The home-based program used resistance bands (Bodylastics International, Boca Raton, FL) and dumbbells and was modeled after a laboratory-based CRT protocol [3,4,5]. Among individuals with tetraplegia and paraplegia, 40-45 min of lab-based CRT performed 3 times weekly for 12 weeks improved peak aerobic capacity (VO2peak) and muscular strength by 31% and 21%, respectively [3,4,5]. Home-based exercise interventions in individuals with SCI have increased VO2peak by 13–39% [6,7,8,9]. Importantly, home-based program participants achieved nearly 100% adherence during a 6–12-week commitment [6,7,8]. Participants indicated that home-based programs were ‘convenient’ [6] and addressed barriers such as lack of access, transportation, and time [7], which are often cited as reasons for not participating in clinical trials [2].

Therefore, the purpose of this paper is to describe the development of a home-based strength and conditioning program; the results of a laboratory-based, proof-of-concept, 8-week training program (development phase) using the home-based program; the outcomes of the home-based program (deployment phase) for the first four phase I ahSC transplantation trial participants; and challenges encountered.

## Methods

We first describe methods used in both the development and deployment phases followed by descriptions of methods unique to each phase. Individuals voluntarily provided written informed consent and completed the University of Miami Institutional Review Board-approved research protocol. Inclusion/exclusion criteria for each study phase are listed in Table 1.

### Development and deployment phases shared methods

#### Peak aerobic capacity assessment

Participants performed a VO2peak assessment using an electronically braked arm-cycle ergometer (Angio, Lode BV, Gronigen, The Netherlands) as previously reported [10]. Participants were asked to refrain from strenuous activity/alcohol or caffeine for 12-h prior to testing. Prior to the first test, a staff member interviewed the participants to determine the individualized wattage starting workload and increments to target a VO2peak in no more than 12-min. The interview included questions regarding the participant’s current fitness program and general activity level. The starting workload and stage increments were kept consistent throughout the assessment periods. Every 1-min workload was increased until volitional exhaustion manifested as either a nonverbal communication of the desire to stop or the inability to maintain cadence at 60 ± 5 rpm. Heart rate (HR) and oxygen consumption were recorded continuously from baseline through recovery. HR was measured by standard 12-lead electrocardiography and expiratory gases were collected and analyzed with an open-circuit metabolic cart (Vmax Encore 29, Care Fusion, San Diego, CA). Peak oxygen consumption (VO2peak), peak power output (POpeak), and time to exhaustion (TTE) were selected for analysis.

### Peak muscular strength assessment

Upper extremity strength testing was performed on a Helms equalizer 1000 multi-station exerciser (Helm Distributing, Polson, MT) using the following six exercises from the laboratory-based CRT: (1) overhead press, (2) horizontal row, (3) chest fly, (4) biceps curl, (5) latissimus pull-down, and (6) triceps press-down (Table 2). We used an iterative, systematic approach whereby participants performed one to three sets of three to five repetitions. Weights for the first set were chosen based on the participant’s injury level, sex, and body weight. Weights for sets two and three were based on participants’ self-rated effort level of the previous set. One-repetition maximum (1-RM) was calculated using the Mayhew regression equation [11], which is validated in persons with SCI [12]:

1-RM = WT/(0.533 + 0.419E − 0.055 × REPS),

where ‘1-RM’ is the estimated one-repetition maximum, ‘WT’ is the resistance used in the last set where more than three, but fewer than eight repetitions are completed, and ‘REPS’ is the repetitions completed in the final set.

### Exercise sequencing and conversion

We deemed the frequent switches between aerobic and strength exercises and between different strength exercises of the laboratory-based CRT program nonfeasible for home-based implementation. We modeled the home-based program exercise sequence after the ‘Tetraplegia’ CRT [4] concurrent model, which consisted of 10 min of aerobic exercise at 60% of HR reserve, followed by all sets of each exercise, and then by 10 min of aerobic exercise also at 60% of HR reserve. For all CRT exercises, we first attempted to recreate the exercise using the resistance band system because it was low-cost, portable, and provided the widest resistance range. We converted the shoulder press and bicep curl to dumbbell exercises. The shoulder press resistance band exercise resulted in a dangerous increase in rearward instability and the biceps curl resistance band exercise could not be completed with good form in a full range of motion.

### Prescription customization session

The prescription customization session objective was, for each exercise, to identify a resistance by repetition combination that achieved (1) a target per set work volume, (2) proper form throughout each repetition, (3) participant stability in their wheelchair, and (4) wheelchair stability. Per set target work volume was computed as ten repetitions × load, with load set at 55% of the predicted 1-RM [13]. This target work volume was the initial volume of the laboratory-based CRT [3]. Figure 1 outlines the iterative process used to identify the band resistance and repetition combination that achieved all goals.

### Home-based concurrent aerobic and resistance training program

Each 50-min aerobic and strength training session was performed 3 times weekly on nonconsecutive days. Participants began with a 2-min low intensity warm up on a Saratoga stationary arm cycle (Rand-Scot, Inc., Fort Collins, CO), followed by 10 min of vigorous intensity. They then performed three sets of 10–20 repetitions (based on the customization session) with no more than 20 s between each set for each of the six exercises. Time between sets mirrored the time allowed in the laboratory-based protocol, which was limited to the time required for the participants to wheel to the next exercise station (generally ~15-s). Participants finished the session with 10 min of vigorous intensity on the stationary cycle [4]. Each 10-min arm-cycle block was self-regulated by the talk test. In order to elicit a vigorous-intensity level, participants were instructed to maintain an intensity that made speaking uncomfortable [14]. Every four weeks, participants completed a 1-RM strength assessment at the laboratory, which was used to increment the target per set work volume and was accompanied by a prescription customization session. Participants in both the development and deployment phases were instructed to maintain their normal activity levels.

### Development phase methods (proof-of-concept training study)

To determine if the home-based program could elicit fitness changes and to determine if participants could execute the home-based program without staff assistance or guidance, two men with chronic thoracic SCI (Table 3) completed an 8-week proof-of-concept study using the home-based program in a laboratory setting to assess the effect of the program on VO2peak, POpeak, and TTE. Participants completed the program 3 times weekly on nonconsecutive days at the Miami Project to Cure Paralysis.

In weeks 1–4, investigators provided physical assistance with setting up each exercise, and verbal guidance regarding form. Participants began the transition to autonomous training in week 5 and were fully autonomous by the end of week 6. During the transition period, staff provided guidance only when participants struggled to remember the next steps in the program or were using improper form. To adjust for conditioning effects, participants’ strength was reassessed, target workloads were re-computed, and a second prescription customization session was completed after 4 weeks. After 8 weeks, participants completed a VO2peak assessment. Figure 2a outlines the assessment and intervention timeline for the development phase proof-of-concept study.

### Deployment phase methods

Four individuals with chronic thoracic SCI (two men and two women) (Table 3) completed the home-based program as a part of their phase I ahSC trial participation. The home-based training program was administered for a 12-week pre transplant conditioning phase with assessments at baseline (PreTxBL) and 1 week prior to the transplant (PreTx). Upon medical clearance, participants resumed training within 1-month post transplant, and continued until 6 months post transplant with assessments at month 2 (PostTxM2) and month 6 (PostTxM6). Figure 2b outlines the timeline of assessments and interventions for the deployment phase.

At PreTxBL and every 4 weeks thereafter, participants completed the muscular strength assessment and an exercise prescription re-customization session. Participants executed the program in their homes or hotel rooms 3 times weekly on nonconsecutive days. The exercise band system, dumbbells, and a Saratoga arm crank were provided to each participant. Participants were supplied with a pictorial exercise guide for reference. Training logs were completed after each session to confirm compliance. Prior to the first at-home session, a member of the study team visited the study participant’s home to ensure proper equipment set-up.

### Outcome measures

Due to small sample size, we present data for each participant at each assessment for both development and deployment phases. The highest 20-s average was selected as VO2peak (ml/min). The highest resistance maintained for at least 20 s was selected as POpeak (W). TTE (minutes:seconds) was recorded as the length of the test. Respiratory exchange ratio (RER), HR, and rate of perceived exertion (RPE) were recorded at peak to confirm that a true peak was achieved. The results are reported as absolute and percent change.

## Results

### Development phase

Both participants increased peak power output (20.0 and 8.7%), peak oxygen consumption (22.9 and 17.9%), and TTE (31.5 and 7.1%) (Table 4). Both participants completed 21 of 24 planned exercise sessions (87.5%), citing illness, and scheduling conflicts as reasons for missing training sessions.

### Deployment phase

#### Pretransplant training phase: PreTxBL to PreTx

Both men increased POpeak (5.9 and 8.3%) and TTE (9.5 and 13.3%) after the 12 weeks of pre transplantation conditioning. The two women had no POpeak changes and slight TTE changes (+2.6 and −1.2%). Interestingly, these minimal effects were accompanied by large divergent VO2peak changes (+13.7% and −19.8%; Table 4; Fig. 3a). Compliance was 92–100% (33–36 completed sessions) for this period.

#### Transplant recovery phase: PreTx to PostTxM2

AhSC transplant surgery was performed immediately following PreTx assessments. The 6-week time period following PreTx to PostTxM2 included 3–5 weeks of post surgery recovery followed by resumed training, dependent upon medical clearance. At PostTxM2, two of four participants (1M, 1F) experienced a decrease in all outcome measures compared with PreTx, with all four participants experiencing a decrease (4.8–28.7%) in TTE (Table 4; Fig. 3b).

#### Posttransplant training phase: PostTxM2 to PostTxM6

All four participants increased TTE between months 2 (PostTxM2) and 6 (PostTxM6) (4.8–24.6%), three increased VO2peak by ≥10%, and two increased POpeak (Table 4, Fig. 3c). Compliance was 90–100% (54–60 sessions) in the 20-week period between PostTxM2 and PostTxM6,

No adverse events were reported in the development phase. Two participants reported aggravation of preexisting joint (shoulder and wrist) pain in the deployment phase. For one of these participants, study staff decreased the starting wattage for the peak aerobic capacity test by 20 W at PostTxM2 and PostTxM6 (Table 4).

## Discussion

A home-based strength and conditioning program is effective and feasible. Our program improved fitness pre- and post-ahSC transplant in four individuals with chronic thoracic SCI, but program effectiveness varied highly. A more robust and universal effect may be achieved by increasing the volume and precision of the aerobic component. Staff burden was reduced, compliance was high, and per-participant study expenditures were moderate. However, there were significant challenges that must be addressed by any group wishing to mimic this approach.

### General effectiveness

Our results suggest a training effect from pretransplant training (PreTxBL to PreTx), detraining following transplant surgery (PreTx to PostTxM2) and finally, a retraining effect after posttransplant training (PostTxM2 to PostTxM6). The largest and most universal improvements occurred during the posttransplant training period (Fig. 3c) and were sufficient to ameliorate posttransplant detraining. We attribute the larger effects observed in the post- vs pretransplant periods to the longer training duration (20 vs 12 weeks). Changes during both training periods were comparable to those reported in individuals of similar ages and injury levels in previous studies that have used the laboratory-based CRT [3, 5]. However, the effectiveness of both periods was highly variable across outcome variables and participants. Such variance is not unexpected, and can be attributed to many factors, such as, but not limited to variability in response to an exercise intervention, day-to-day variability in peak performance during testing; training above/below the prescribed intensity; and insufficient training intensity.

### Variance in effectiveness & proposed solutions

There is strong evidence for considerable natural variation in individual responses (including nonresponse) to exercise training programs, even when all research participants are subjected to the same volume and relative intensity of physical activity [15]. Mean response of a group to an exercise intervention can mask individual differences in direction and magnitude [15]. As a hypothetical example, a training study might report a 25% mean gain above baseline values in VO2max, however, the range of improvement actually varied from no gain to a doubling of baseline values [16]. It is generally accepted that some individuals are unable to mount a strong physiological response to an exercise training intervention [17]. The heterogeneity in the physiological responses to our exercise program may be explained in part by the natural variance in physiological response to a training stimulus (Fig. 3). However, it may also be explained by natural test–retest fluctuation and/or error in measurement. Establishing true and meaningful individual differences in training programs responses would have required including a comparator sample and assessing aerobic capacity multiple times at each assessment point. These features were not possible is this study. As phase I clinical trial, per FDA regulations a comparator group was not allowed in the ahSC trial. Practical constraints on the cumulative time burden of testing at each assessment point were a barrier to administering multiple aerobic tests at each assessment. A week was required to complete all primary (full ISNCSCI motor and sensory assessments, MRI, pain and sensory assessments, basic blood chemistry) and secondary (functional, fitness, electrophysiological, autonomic, quality of life, and spasticity assessments) outcomes.

Nonetheless, a physiologic nonresponse to exercise in one metric is not indicative of a ubiquitous nonresponse. In the deployment phase, despite POpeak and TTE improvements, some individuals saw no increase or a slight decrease in VO2peak (Fig. 3). The emphasis of strength over the aerobic component in our home-based program likely favored gains in power over aerobic capacity. The aerobic component (60 min/week) falls well below the generally recommended 150 min of moderate-intensity aerobic exercise per week [18, 19], however, it does comply with recently published scientific guidelines for improving cardiorespiratory fitness in adults with SCI [20]. However, aerobic exercise intensity may be more important than duration. Several studies have reported superior improvements in cardiorespiratory fitness in individuals with SCI performing vigorous-intensity exercise [21]. Our participants may have executed the aerobic component at an intensity below the prescribed vigorous intensity. While the prescribed duration and intensity of the aerobic component was sufficient for some participants to improve or maintain their aerobic capacity, it was likely inadequate for individuals who entered the study with a high aerobic capacity, resulting in a ceiling effect or even detraining.

We did not consider participants’ current physical activity level when developing the program. This led to a detraining effect for one deployment phase participant who, prior to relocating for clinical trial participation, was hand cycling up to 10 h each week. This highly trained individual was accustomed to a significantly greater training volume than our program offered, was unable to maintain his pretrial weekly hand-cycling program, and thus did not maintain his initial fitness level. Detraining can occur if the program training volume is less than the participant’s current dosing. Thus, future implementations in any domain, including FES or gait training, should be flexible enough to achieve conditioning gains in under-conditioned persons and maintain the conditioning of persons who enter the trial at a supra-optimal status. In addition, each individual’s response to the training stimulus should be reassessed frequently in order to intensify training for nonresponders.

### Compliance, participant-staff burden, program materials cost

High program compliance was consistent with interventions of similar content and duration [6,7,8]. However, compliance was an explicitly stated expectation for trial participation. Individuals who presented themselves as candidates were removed from consideration if there was any doubt about their willingness and ability to comply with the multimodal pre- and posttransplant training. In addition, all participants were required to be of ‘average’ or greater fitness classification [22] to undergo transplantation. Study participants were informed of their current fitness classification following baseline testing and were likely motivated to complete the training in order to maintain or achieve the minimum fitness required to undergo transplantation surgery. In this particular cohort, both male participants fell in the ‘excellent’ fitness category at baseline and maintained that throughout the trial. One female participant was above median and one below at baseline. The female who was below median at baseline (and thus not initially eligible to undergo transplantation) improved to above median after pretransplant conditioning and was approved for surgery.

Participant and staff burden were decreased as a result of the home-based program. Participants did not express that they felt overburdened, in fact, three of four participants requested permission to perform more physical activity.

The average cost per participant (paid for by the trial) was US$2160–2258. This includes the arm cycle (US$1920), resistance bands and door anchor (US$198), and dumbbells (US$42–140).

### Home-based program development and deployment challenges

We encountered multiple sets of challenges during home-based program development and deployment. The first set included maintaining participant stability in the chair and stability of the wheelchair itself. We used 55% of 1-RM values calculated during the 1-RM assessment as a starting point to set resistive loads on the band training system. This resistance resulted in a complete loss of balance when the maneuver was performed bilaterally due to lack of trunk motor control. Therefore we switched to performing the exercises unilaterally which also resulted in a complete loss of balance. To solve this problem we switched to a volume based paradigm, which allowed us to reduce the resistance to a level that enabled the participant to maintain stability by using their ipsilateral arm to grab their chair. However, even when participant stability was maintained, the wheelchair often slid across the low friction tile floor toward the anchor point of the bands. This problem was solved for all participants by requiring the resistance band system be installed in a room with a carpeted floor. If this is not possible, individuals can place a small mat on a low friction floor or, if they are able to, place wood 2 × 4 s in front of the rear wheels.

The second set was ensuring participants could independently perform all exercises at home with the prescribed resistance and correct form. Band resistance is dependent on the degree of stretch, which in turn is dependent on how far the individual is from the band’s anchor point, and thus must be consistent across training sessions. During the prescription customization session, for each maneuver, the wheelchair’s position relative to and distance from the anchor point was documented. When participants returned home, they marked the wheelchair position for each exercise on the floor with a piece of tape, which enabled consistent band resistance across sessions. Customization sessions were also used to correct and coach participants on proper form, and included key tips for each exercise. To further facilitate compliance, participants were provided with a packet after each customization session that described for each exercise where to place tape markers, which bands to use, the anchor points, the required number of sets and reps, photos of the start and end positions, and training logs for each session. If requested, a staff member traveled back to the participant’s residence after each prescription customization session to check the tape markers and band system set-up. For exercises where the tape markers resulted in a position more than an arm length from the band anchor, a piece of rope was tied to the resistance band’s handle. Participants placed the rope in their lap while they assumed the prescribed position and then used the rope to pull the handle toward them. Finally, to prevent the participant from having to re-configure the bands for each exercise during the session, a unique set of bands were provided for each exercise. The bands for each exercise were attached to the anchor system after each customization session and remained in place until the next prescription customization session.

To our knowledge, these challenges have not been specifically reported by other studies investigating the use of a home-based band resistance training program [8, 23] in individuals with SCI. In a case series [8], the participant spent 90 min with study staff learning the details and correct form for the exercises and establishing the proper band resistance. Band resistance was established by identifying a challenging load during the last three repetitions in a set of ten [8]. An earlier study used 50% of 1-RM established on the laboratory-based CRT exercises to convert into band resistance equivalents by attaching 20-cm loops of band to a calibrated tensiometer [23]. The authors of previous studies did not specifically address any challenges regarding chair stability or the ability to achieve the desired training volume using these methods.

### Methodological weaknesses and limitations

The small sample size limits statistical analysis as well as generalizability of findings, however, this limitation is inherent to all phase I trials. Participation in this clinical trial required that participants relocated to the Miami area for 10 months. This substantial environmental change likely affected general living habits, especially diet and exercise/rehabilitation participation, for which we did not account. Our compliance monitoring was based on self-report and therefore we could not verify that each session was actually performed. Finally, testing bias was possible, as the investigator performing the prescription customizations was also, at times, conducting VO2peak assessments. Ideally, the individual conducting the VO2peak assessment would be blinded to the prescription customization and to the participants’ mid-assessment progress.

## Conclusions

Home-based strength and condition programs can be successfully included in therapeutic SCI trials and can be effective to achieve target fitness levels. However, development of these programs requires substantial content knowledge and experience. In addition, for each mode of a multimodal condition program designed to support an intervention, future studies should strongly consider customizing training loads for highly trained persons in addition to a standardized training load for nontrained participants.

## Data availability

All data generated and analyzed in this study are available from the corresponding author on request.

## References

1. Gant KL, Nagle KG, Cowan RE, Field-Fote EC, Nash MS, Kressler J, et al. Body system effects of a multi-modal training program targeting chronic, motor complete thoracic spinal cord injury. J Neurotrauma. 2018;35:411–23.

2. Anderson KD, Cowan RE, Horsewell J. Facilitators and barriers to spinal cord injury clinical trial participation: multi-national perspective of people living with spinal cord injury. J Neurotrauma. 2016;33:493–9.

3. Jacobs PL, Nash MS, Rusinowski JW. Circuit training provides cardiorespiratory and strength benefits in persons with paraplegia. Med Sci Sports Exerc. 2001;33:711–7.

4. Kressler J, Burns PA, Betancourt L, Nash MS. Circuit training and protein supplementation in persons with chronic tetraplegia. Med Sci Sports Exerc. 2014;46:1277–84.

5. Nash MS, van de Ven I, van Elk N, Johnson BM. Effects of circuit resistance training on fitness attributes and upper-extremity pain in middle-aged men with paraplegia. Arch Phys Med Rehabilit. 2007;88:70–5.

6. Lai B, Rimmer J, Barstow B, Jovanov E, Bickel CS. Teleexercise for persons with spinal cord injury: a mixed-methods feasibility case series. JMIR Rehabilit Assist Technol. 2016;3:e8.

7. Nightingale TE, Walhin JP, Thompson D, Bilzon JLJ. Impact of exercise on cardiometabolic component risks in spinal cord-injured humans. Med Sci Sports Exerc. 2017;49:2469–77.

8. Sasso E, Backus D. Home-based circuit resistance training to overcome barriers to exercise for people with spinal cord injury: a case study. J Neurol Phys Ther. 2013;37:65–71.

9. Ma JK, West CR, Martin Ginis KA. The effects of a patient and provider co-developed, behavioral physical activity intervention on physical activity, psychosocial predictors, and fitness in individuals with spinal cord injury: a randomized controlled trial. Sports Med. 2019;49:1117–31.

10. Maher JL, Cowan RE. Comparison of 1- versus 3-minute stage duration during arm ergometry in individuals with spinal cord injury. Arch Phys Med Rehabilit. 2016;97:1895–900.

11. Mayhew JL, Prinster JL, Ware JS, Zimmer DL, Arabas JR, Bemben MG. Muscular endurance repetitions to predict bench press strength in men of different training levels. J Sports Med Phys Fit. 1995;35:108–13.

12. Ribeiro Neto F, Guanais P, Dornelas E, Coutinho ACB, Costa RRG. Validity of one-repetition maximum predictive equations in men with spinal cord injury. Spinal Cord. 2017;55:950–6.

13. Benson C, Docherty D, Brandenburg J. Acute neuromuscular responses to resistance training performed at different loads. J Sci Med Sport. 2006;9:135–42.

14. Cowan RE, Ginnity KL, Kressler J, Nash MS, Nash MS. Assessment of the talk test and rating of perceived exertion for exercise intensity prescription in persons with paraplegia. Top Spinal Cord Inj Rehabilit. 2012;18:212–9.

15. Bouchard C, Rankinen T. Individual differences in response to regular physical activity. Med Sci Sports Exerc. 2001;33:S446–51.

16. Bouchard C. Individual differences in the response to regular exercise. Int J Obes Relat Metab Disord. 1995;19(Suppl 4):S5–8.

17. Timmons JA. Variability in training-induced skeletal muscle adaptation. J Appl Physiol. 2011;110:846–53.

18. Nash MS, Groah SL, Gater DR Jr, et al. Identification and Management of Cardiometabolic Risk after Spinal Cord Injury: Clinical Practice Guideline for Health Care Providers. Top Spinal Cord Inj Rehabil. 2018;24:379–423. https://doi.org/10.1310/sci2404-379.

19. American College of Sports Medicine, Riebe D, Ehrman JK, Liguori G, Magal M. ACSM’s guidelines for exercise testing and prescription. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2018.

20. Martin Ginis KA, van der Scheer JW, Latimer-Cheung AE, Barrow A, Bourne C, Carruthers P, et al. Evidence-based scientific exercise guidelines for adults with spinal cord injury: an update and a new guideline. Spinal Cord. 2018;56:308–21.

21. Nightingale TE, Metcalfe RS, Vollaard NB, Bilzon JL. Exercise guidelines to promote cardiometabolic health in spinal cord injured humans: time to raise the intensity? Arch Phys Med Rehabilit. 2017;98:1693–704.

22. Simmons OL, Kressler J, Nash MS. Reference fitness values in the untrained spinal cord injury population. Arch Phys Med Rehabilit. 2014;95:2272–8.

23. Nash MS, Jacobs PL, Woods JM, Clark JE, Pray TA, Pumarejo AE. A comparison of 2 circuit exercise training techniques for eliciting matched metabolic responses in persons with paraplegia. Arch Phys Med Rehabilit. 2002;83:201–9.

## Acknowledgements

The authors would like to acknowledge the work of Kathleen Nagle.

### Funding

This work was supported by The Miami Project to Cure Paralysis, Buoniconti Fund to Cure Paralysis, and the Bryon Riesch Paralysis Foundation.

## Author information

Authors

### Contributions

All authors were responsible for research conception and design and critical review and revision of the article. JM, REC, and KDA were involved converting the CRT exercises to band/dumbbell exercises. JM was additionally involved in data collection, analysis, and drafting this paper.

### Corresponding author

Correspondence to Jennifer L. Maher.

## Ethics declarations

### Conflict of interest

The authors declare that they have no conflict of interest.

### Ethical approval

We certify that all applicable institutional and governmental regulations concerning the ethical use of human volunteers were followed during the course of this research.

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Maher, J.L., Anderson, K.D., Gant, K.L. et al. Development and deployment of an at-home strength and conditioning program to support a phase I trial in persons with chronic spinal cord injury. Spinal Cord 59, 44–54 (2021). https://doi.org/10.1038/s41393-020-0486-7

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• DOI: https://doi.org/10.1038/s41393-020-0486-7