Article | Published:

Passive limb movement intervals results in repeated hyperemic responses in those with paraplegia

Spinal Cord (2018) | Download Citation

Abstract

Study design

Repeated measures.

Objectives

Reports suggest passive limb movement (PLM) could be used as a therapy to increase blood flow and tissue perfusion in the paralyzed lower limbs of those with spinal cord injuries. However, the hyperemic response to PLM appears to be transient, lasting only 30–45 s despite continued limb movement. The purpose of this investigation was to determine whether the hyperemic response is repeatable across multiple short bouts of passive limb movement.

Setting

Cleveland Veterans Affairs Medical Center.

Methods

Nine individuals with paraplegia 46 ± 6 years of age, 17 ± 12 years post injury (range: 3–33 years) with complete T3–T11 injuries were subject to 5 × 1 min bouts of passive knee extension/flexion at 1 Hz with a 1 min recovery period between each bout. Heart rate (HR), mean arterial pressure (MAP), femoral artery blood flow (FABF), skin blood flow (SBF), and tissue perfusion in the lower limb were recorded during baseline and throughout each bout of PLM.

Results

Despite no increase in HR (p ≥ 0.8) or MAP (p ≥ 0.40) across all four bouts of PLM, the average increase in FABF during each bout ranged from 71 ± 87% to 88 ± 93% greater than baseline (p ≤ 0.043). SBF also increased between 465 ± 302% and 582 ± 309% across the five bouts of PLM (p ≤ 0.005).

Conclusions

Repeated bouts of PLM in those with SCI while in an upright position resulted in a robust and steady increase in FABF and SBF which could have implications for improving vascular health and tissue perfusion in the lower limbs of those with paraplegia.

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Acknowledgements

This work was supported by SPIRE award 1121 RX001732-01A1 from the United States Department of Veterans Affairs Rehabilitation Research and Development Service. The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government

Author information

Affiliations

  1. Department of Exercise Science, Walsh University, North Canton, OH, USA

    • Keith J. Burns
    •  & Brandon S. Pollock
  2. Heart and Vascular Institute, Penn State College of Medicine, Hershey, PA, USA

    • Jon Stavres
  3. Advanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA

    • Martin Kilbane
    • , Amber Brochetti
    •  & John McDaniel
  4. Department of Exercise Physiology, Kent State University, Kent, OH, USA

    • John McDaniel

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Conflict of interest

The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to John McDaniel.

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DOI

https://doi.org/10.1038/s41393-018-0099-6