Article

Spinal cord injury and Alzheimer’s disease risk: a population-based, retrospective cohort study

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Abstract

Study design

Propensity score-matched, retrospective cohort study.

Objectives

To determine the risk of developing Alzheimer’s disease (AD) in patients with spinal cord injury (SCI).

Setting

The present study used Taiwan’s National Health Insurance Research Database.

Methods

A total of 9257 patients who had 2 ambulatory visits with a diagnosis of SCI in 2001 were included in the SCI group. The non-SCI group consisted of 37,028 propensity score-matched patients without a diagnosis of SCI. The cumulative incidence of AD was estimated for each of the two patient groups using the Kaplan–Meier method. Stratified Cox proportional hazard regression was then employed to assess the influence of SCI on the risk of AD.

Results

During the follow-up period, 25 subjects in the SCI group and 57 in the non-SCI group developed AD. The cumulative incidence of AD in the SCI group was higher than in the non-SCI group (P = 0.0168); and the hazard ratio of AD for the SCI group, as compared to the non-SCI group, was 1.71 (95% CI 1.06–2.76, P = 0.0273).

Conclusions

This study suggests that patients with SCI have an increased risk of developing AD.

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Acknowledgements

This work was supported by the Department of Health, Executive Yuan, Republic of China [DOH93-TD-M-113-030, DOH94-TD-M-113-004, and DOH95-TD-M-113-002].

Author information

Author notes

    Affiliations

    1. Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan

      • Tian-Shin Yeh
    2. Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan

      • Yu-Chun Ho
      •  & Shin-Liang Pan
    3. Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan

      • Cherng-Lan Hsu
    4. Department of Physical Medicine and Rehabilitation, National Taiwan University College of Medicine, Taipei, Taiwan

      • Shin-Liang Pan

    Authors

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    Conflict of interest

    The authors declare that they have no competing interests.

    Funding

    The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

    Corresponding author

    Correspondence to Shin-Liang Pan.