Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients

Fig. 3

The inhibitory effects of circulating exosomes on SARS-CoV-2 replication were decreased in elderly people and diabetic patients. a Diagrams of the collection of exosomes from serum in young, elderly and diabetic groups and the measurement of the biological activities of exosomes in inhibiting S protein expression and SARS-CoV-2 replication. b Efficacy of exosomes collected from young, elderly and diabetic groups in inhibiting the replication of SARS-CoV-2. c, d, e Cytometric analysis (c), fluorescence images (d) and western blot (e) of GFP-S protein-overexpressing HEK293T cells after treatment with PBS and serum exosomes collected from the young, elderly and diabetic groups. Data are shown as means ± SEMs. Statistical significance was assessed using one-way ANOVA coupled with Bonferroni’s post hoc test (b, c, e). *P < 0.05; **P < 0.01; ***P < 0.001

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