Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Eosinophil-derived chemokine (hCCL15/23, mCCL6) interacts with CCR1 to promote eosinophilic airway inflammation

Fig. 1

Increased expressions of hCCL23 and hCCL15 in asthma patients. a Relative mRNA expressions of hCCL23 and hCCL15 in total white blood cells (WBCs) from asthma patients (n=16) versus healthy control subjects (n=16). b hCCL23 concentration measured by ELISA in the plasma of asthma patients (n=31) compared with healthy control (n=30). Data in a and b are presented as median (centerline), and the whiskers indicate no more than 1.5 times the interquartile range (the difference between 25th and 75th percentiles, shown in the box). c Correlation of hCCL23 protein levels with the number of eosinophils in human peripheral blood (n=61, linear regression and Spearman rank correlation). d Schematic illustration of peripheral blood WBCs isolating procedure from asthma patients. e Representative images of total WBCs and isolated subsets slides of Wright-Giemsa staining and immunofluorescence staining for EPX (green), hCCL23 (red), hCCL15 (red), and DAPI (blue). Scale bar, 40μm. Insets show high-power images in the upper right corner of each overlay. Scale bar, 10μm. **P<0.01 by unpaired t-test

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